Martin Lercher
@martinlercher.bsky.social
Researchee & Night Scientist
Genes transferred together often remain neighbors, so we use genomic data to test real-world accuracy.
Fig. 2 is key:
🔺 Implicit methods (GLOOME, Count) vastly outperform others.
🔻 Explicit methods relying on gene trees show fewer co-transferred neighbors, suggesting higher false-positive rates.
Fig. 2 is key:
🔺 Implicit methods (GLOOME, Count) vastly outperform others.
🔻 Explicit methods relying on gene trees show fewer co-transferred neighbors, suggesting higher false-positive rates.
August 4, 2025 at 10:33 AM
Genes transferred together often remain neighbors, so we use genomic data to test real-world accuracy.
Fig. 2 is key:
🔺 Implicit methods (GLOOME, Count) vastly outperform others.
🔻 Explicit methods relying on gene trees show fewer co-transferred neighbors, suggesting higher false-positive rates.
Fig. 2 is key:
🔺 Implicit methods (GLOOME, Count) vastly outperform others.
🔻 Explicit methods relying on gene trees show fewer co-transferred neighbors, suggesting higher false-positive rates.
How can we best infer horizontal gene transfer (HGT) in prokaryotes?
Our new study finds a surprising winner: gene presence–absence patterns beat explicit phylogenetic approaches!
📄 Mishra & Lercher (2025), Mol Biol Evol
🔗 doi.org/10.1093/molb...
Our new study finds a surprising winner: gene presence–absence patterns beat explicit phylogenetic approaches!
📄 Mishra & Lercher (2025), Mol Biol Evol
🔗 doi.org/10.1093/molb...
August 4, 2025 at 10:29 AM
How can we best infer horizontal gene transfer (HGT) in prokaryotes?
Our new study finds a surprising winner: gene presence–absence patterns beat explicit phylogenetic approaches!
📄 Mishra & Lercher (2025), Mol Biol Evol
🔗 doi.org/10.1093/molb...
Our new study finds a surprising winner: gene presence–absence patterns beat explicit phylogenetic approaches!
📄 Mishra & Lercher (2025), Mol Biol Evol
🔗 doi.org/10.1093/molb...