4/
🎉 Proud to share this work with co-first author Paula Brown and the Yao lab.
Big thanks to the Mouse Model Core for making this possible! Use it. Share it. Build with it.
🧬 #DevBio #ReproSci

3/
Our model shows:
✅ High specificity for interstitial cells
✅ Activity in embryonic and adult reproductive tissues
✅ No recombination in Sertoli, granulosa, or germ cells
✅ Can also label Nr2f2+ lineages in other organs (lung, kidney)

2/
Most Cre lines used in gonadal research focus on supporting or germ cells.
The interstitium? Often neglected, despite its essential roles in steroidogenesis, structural support, and signaling.
We wanted to fix that. 🧬