Marteinn Snæbjörnsson
@marteinnsn.bsky.social
Fantastic!
Congratulations 🙂
Congratulations 🙂
March 5, 2025 at 3:30 PM
Fantastic!
Congratulations 🙂
Congratulations 🙂
This was very much a collaborative effort of the Schulze lab and I would like to thank my current as well as previous coworkers for their key role in bringing this work to light.
Thanks likewise to Alpaslan Tasdogan and coworkers for writing a fantastic News & Views about our work.
Thanks likewise to Alpaslan Tasdogan and coworkers for writing a fantastic News & Views about our work.
Aldolase A: the broker of glycolysis - Nature Metabolism
Aldolase A is one of the glycolytic enzymes that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an...
www.nature.com
January 22, 2025 at 8:37 AM
This was very much a collaborative effort of the Schulze lab and I would like to thank my current as well as previous coworkers for their key role in bringing this work to light.
Thanks likewise to Alpaslan Tasdogan and coworkers for writing a fantastic News & Views about our work.
Thanks likewise to Alpaslan Tasdogan and coworkers for writing a fantastic News & Views about our work.
This effectively converts glycolysis from an energy producing to an energy consuming pathway in cells that don't really need glycolysis to generate energy. Key to understanding our data was reading the previous work of Bas Teusink lab (PMID: 24436182) in yeast.
January 22, 2025 at 8:36 AM
This effectively converts glycolysis from an energy producing to an energy consuming pathway in cells that don't really need glycolysis to generate energy. Key to understanding our data was reading the previous work of Bas Teusink lab (PMID: 24436182) in yeast.
Inhibiting Aldolase A leads to imbalanced glycolysis (the investment phase outpaces the payoff phase) where high energy phosphate from ATP is used to synthesize an ever increasing pool of the (high energy) glycolytic intermediate FBP.
January 22, 2025 at 8:35 AM
Inhibiting Aldolase A leads to imbalanced glycolysis (the investment phase outpaces the payoff phase) where high energy phosphate from ATP is used to synthesize an ever increasing pool of the (high energy) glycolytic intermediate FBP.
Using a combination of metabolomics but also mathematical modeling in collaboration with Prof. Ralf Steuer and Daria Komkova we found that this counterintuitive result is explained by the biphasic and auto-catalytic nature of glycolysis.
January 22, 2025 at 8:34 AM
Using a combination of metabolomics but also mathematical modeling in collaboration with Prof. Ralf Steuer and Daria Komkova we found that this counterintuitive result is explained by the biphasic and auto-catalytic nature of glycolysis.
We discovered that depleting or knocking out the enzyme Aldolase A in liver cancer lead to cell cycle arrest. Surprisingly, completely blocking glycolysis by knocking out the enzyme GPI upstream of Aldolase in glycolysis was fully tolerated as metabolic reprogramming allowed the cells to adapt.
January 22, 2025 at 8:33 AM
We discovered that depleting or knocking out the enzyme Aldolase A in liver cancer lead to cell cycle arrest. Surprisingly, completely blocking glycolysis by knocking out the enzyme GPI upstream of Aldolase in glycolysis was fully tolerated as metabolic reprogramming allowed the cells to adapt.