Marion Pepper
@marionpepper.bsky.social
Immunologist. Immune memory.👩🏻🔬
Our findings argue that modulating TCF1+ Trm will be important for either suppressing chronic inflammatory diseases or boosting long-lived immune protection. Huge thanks to the many people who contributing to this beast and the NIH-funding that supported it.
October 10, 2025 at 7:22 PM
Our findings argue that modulating TCF1+ Trm will be important for either suppressing chronic inflammatory diseases or boosting long-lived immune protection. Huge thanks to the many people who contributing to this beast and the NIH-funding that supported it.
TCF1+ cells in the tissue and highlight the TLS core as an important inhibitory niche otherwise absent in the lung tissue. Additional data from our lab and others supports that these two CD4+ Trm populations exist in multiple tissues in multiple diseases and inflammatory conditions.
October 10, 2025 at 7:22 PM
TCF1+ cells in the tissue and highlight the TLS core as an important inhibitory niche otherwise absent in the lung tissue. Additional data from our lab and others supports that these two CD4+ Trm populations exist in multiple tissues in multiple diseases and inflammatory conditions.
we could see differences in core signatures at the center of the TLS compared to the outer ring of the TLS, with inhibitory receptor-ligand pairs (PD1/PDL1/PDL2) predominantly expressed in the core. Experiments using PD1 blockade highlight the significant role of PD1 signaling in maintaining...
October 10, 2025 at 7:22 PM
we could see differences in core signatures at the center of the TLS compared to the outer ring of the TLS, with inhibitory receptor-ligand pairs (PD1/PDL1/PDL2) predominantly expressed in the core. Experiments using PD1 blockade highlight the significant role of PD1 signaling in maintaining...
Citeseq data acquired with the ImmGenT consortium (@immgen.bsky.social) and spatial transcriptomics acquired with the @alleninstitute.org, which allowed for the visualization of transcriptional programs expressed by CD4+ Trm across distance from the TLS to the airways. Even cooler...
October 10, 2025 at 7:22 PM
Citeseq data acquired with the ImmGenT consortium (@immgen.bsky.social) and spatial transcriptomics acquired with the @alleninstitute.org, which allowed for the visualization of transcriptional programs expressed by CD4+ Trm across distance from the TLS to the airways. Even cooler...
a TCF1+ population that resides in tertiary lymphoid structures (TLS) and serves as a memory progenitor population for pathological Th2 effectors that reside at the airway interface. Through a collaborative tour de force, we integrated....
October 10, 2025 at 7:22 PM
a TCF1+ population that resides in tertiary lymphoid structures (TLS) and serves as a memory progenitor population for pathological Th2 effectors that reside at the airway interface. Through a collaborative tour de force, we integrated....
What Derek Bangs PhD and colleagues found reveals important insights for treating diseases of chronic inflammation in the tissues. Allergen-specific CD4+ Trm were comprised of two functionally and geographically distinct populations:
October 10, 2025 at 7:22 PM
What Derek Bangs PhD and colleagues found reveals important insights for treating diseases of chronic inflammation in the tissues. Allergen-specific CD4+ Trm were comprised of two functionally and geographically distinct populations:
💔 he did this for so many of us.
August 30, 2025 at 7:26 AM
💔 he did this for so many of us.