Maria Glymour
mariaglymour.bsky.social
Maria Glymour
@mariaglymour.bsky.social
Professor and Chair of the Department of Epidemiology at Boston University School of Public Health
I’m really interested in how early financial decision making deteriorations are detectable.
November 2, 2025 at 4:47 PM
Because dementia may *typically* have multiple etiologies, and the biological processes culminating in "disease" slowly accumulate damage from almost nothing to devastating, choosing a criterion for a "yes/no" categorization is fundamentally challenging.
November 2, 2025 at 2:59 PM
Bottom line it's somewhat shocking that such a major public health challenge is frequently redefined by a group of people with financial incentives for a particular type of definition and without careful consideration of how to resolve problems induced by prior definitions.
November 2, 2025 at 2:59 PM
I also thought (& I'd love others opinions) that the McKhan criteria used 1984-2007 led to bias in AD dx b/c people with a history of stroke were excluded (classed as multi-infact) and I suspect major risk factors for stroke were considered evidence against AD and for multi-infarct. #EpiSky
November 2, 2025 at 2:59 PM
Thank you -I'm still getting the hang of these interwebs.
October 23, 2025 at 11:26 PM
Reposted by Maria Glymour
I will add that at the end of September, the Tulsa World had a major layoff enforced by the parent company. The editor in chief Jason Collington apparently quit rather than presiding over the layoffs. It seems like a huge loss for a city and state that deserves outstanding community news.
October 17, 2025 at 3:31 AM
Ooh, Jennifer Weuve asks about promise/perils of microRNA. A: it's really an epigenetic thing - it modifies protein expression, often of multiple proteins.
October 16, 2025 at 3:48 PM
Great q from Emma Nichols: given rapid changes in biomarkers, what should studies be collecting? A: try storing tissue samples, so you can go back and look later as the tools evolve.
October 16, 2025 at 3:48 PM
Wow, photo on her final slide suggests that everyone at their ADRC gets a cowboy hat. Puts a new emphasis on "partner"ships. Very cute. (reminds me of this time my grandpa wore a bolo tie to dinner with one of my friends from NYC and she asked him if he was being ironic. he was not.)
October 16, 2025 at 3:48 PM
One thing to note is that many things we call "alzheimer's markers" are actually "dementia markers". Even with biomarkers, we need to think about both global (eg NFL) and more specific biomarkers. Don't get attached to any one marker yet!
October 16, 2025 at 3:48 PM
Guiding treatment, eg who is at most risk of ARIA.
October 16, 2025 at 3:48 PM
Thought perhaps we can augment biomarker information with genetic information (as recently demonstrated for prostate cancer). EG can we distinguish AD, DLB/PD, VCID probabilistically based on genetic risk? Can we identify genetic modifiers of response to multi-modal interventions?
October 16, 2025 at 3:48 PM