Marc Niebel
marcniebel.bsky.social
Marc Niebel
@marcniebel.bsky.social
Bioinformatician & Clinical Scientist. Sports enthusiast. Opinions are my own
Reposted by Marc Niebel
Grateful to @marionkoopmans.bsky.social for writing this thoughtful piece in Nature Rev Micro. We can’t push back against anti-science movements without taking the threat seriously, proactively address our limitations, and engage with the public clearly & candidly.

www.nature.com/articles/s41...
Anti-science and the science community
Nature Reviews Microbiology - As anti-science sentiment intensifies — aggravated by the pandemic, driven in some parts of the world by political actors and amplified by social media —...
www.nature.com
August 13, 2025 at 8:20 PM
Reposted by Marc Niebel
📢New job posting!📢
Are you excited by the idea of building global infrastructure to make pathogen sequencing more accessible, interpretable, and equitable? 🧑🏻‍💻🧬

My group at @swisstph.ch has an opening working with ARTIC2, @pathoplexus.org, & Loculus - read on!

1/5
July 25, 2025 at 10:44 AM
Reposted by Marc Niebel
Some great new features and updates from the awesome Pathoplexus project. This is a new open pathogen genome database that can provide access to your sequences under a use-restricted license but also feed directly in to INSDC (EBI, Genbank etc) when you are ready. pathoplexus.org/news/2025-07...
Pathoplexus | Pathoplexus July Update
Pathoplexus is a new, open-source database dedicated to the efficient sharing of human viral pathogen genomic data, fostering global collaboration and public health response.
pathoplexus.org
July 15, 2025 at 2:05 PM
Reposted by Marc Niebel
Absolutely thrilled to announce the launch of ARTIC2 - a £5.5M 5 year project funded by @wellcometrust.bsky.social to build on the ARTIC approach of low-cost, globally accessible genome sequencing for surveillance of outbreaks, epidemics and endemic diseases: www.birmingham.ac.uk/news/2025/am...
Ambitious project to develop low-cost genome sequencing for pathogens known and unknown - University of Birmingham
Project will build on research that helped diagnostic labs to adopt sequencing capacity for COVID-19 and permit characterisation of future infectious threats
www.birmingham.ac.uk
May 22, 2025 at 10:57 AM
Reposted by Marc Niebel
@sundermannaj.bsky.social's work highlights the undeniable impacts of pathogen genomics in healthcare. But pathogen genomics in healthcare remains the exception, not the norm.

We spent an hour exploring the challenges and potential solutions to more broad adoption.

www.youtube.com/watch?v=XDLo...
Pathogen Genomics in Healthcare with Alex Sundermann
YouTube video by The Bioinformatics Lab
www.youtube.com
May 14, 2025 at 8:10 PM
Reposted by Marc Niebel
New work in Nature shows that a brief 5-day CIP course in (n=60) healthy adults can lead to emergence of AMR in ~10% of ~5600 gut microbial species. Most mutations in gyrA (known FQ hotspots), do not affect fitness & can be detected >10wks (projected to persist >1y)
🔗 www.nature.com/articles/s41...
Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
www.nature.com
April 24, 2025 at 7:43 AM
Reposted by Marc Niebel
Thanks to @lancetmicrobe.bsky.social for featuring our mSCAPE metagenomics surveillance collaboration and also thanks for the considered comments from Mario Falchi and Judy Breuer: www.thelancet.com/journals/lan... - keep an eye out on mSCAPE.climb.ac.uk for further details and resources
UK launch metagenomic pathogen surveillance programme
On Jan 30, 2025, the UK Health Security Agency (UKHSA) announced the launch of the metagenomics Surveillance Collaboration and Analysis Programme (mSCAPE)—the world’s first biosecurity surveillance sy...
www.thelancet.com
April 24, 2025 at 1:55 PM
Reposted by Marc Niebel
'The UK has a new watch list of 24 infectious diseases that could pose the greatest future threat to public health'

www.bbc.co.uk/news/article...
Priority pathogens: UK draws up new disease-threat watch list
Some are viruses with global pandemic potential - like Covid - others infectious illnesses with no treatments.
www.bbc.co.uk
March 25, 2025 at 7:07 AM
Reposted by Marc Niebel
In our latest review, we explore 12 deep-learning tools for metagenomic analysis, covering their strengths, limitations, and key applications. We hope it serves as both a resource and inspiration for new ways to analyze metagenomic data. Great work by Eli Levy Karin!
📄 doi.org/10.1093/nsr/...
February 22, 2025 at 5:47 AM
Reposted by Marc Niebel
Wendy Barclay and I are recruiting a postdoc for a project investigating the evolution of swine influenza viruses and how this impacts future pandemic potential.

Job is based at Imperial's South Kensington campus. Drop me a DM/email for more details.
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
January 16, 2025 at 2:29 PM
Reposted by Marc Niebel
We are hiring remote bioinformaticians at @theiagen . If you have a passion for microbial bioinformatics or public health, send your CV to careers@theiagen.com . You can be based nearly anywhere but need to be available to work US business hours.
December 5, 2024 at 2:46 PM
Reposted by Marc Niebel
Today is #WorldAIDSDay. Observed every 1 December, it stands as a global initiative uniting people to raise awareness about HIV/AIDS & demonstrate solidarity in the face of the epidemic.

It serves as a reminder of the ongoing challenges posed by HIV/AIDS & underscores the need for sustained action.
World AIDS Day 2024
World AIDS Day, observed every year on 1 December, stands as a global initiative uniting people worldwide to raise awareness about HIV/AIDS and demonstrate international solidarity in the face of the ...
bit.ly
December 1, 2024 at 12:03 PM