Manan Shah
@mananshah.bsky.social
Postdoc @ UNSW Sydney in the Crossley and Quinlan Labs. Molecular biologist interested in gene regulation, transcription factors, chromatin, and epigenetics. Occasional bioinformatician.
Reposted by Manan Shah
Our latest paper, my 9th in one of my favourite journals
@narjournal.bsky.social
- transcriptional cofactors don’t just help in gene activation, they also help guide their partner transcription factors to target genes academic.oup.com/nar/article/... ##zincfingers #chromatin #epigenetics #KLF
@narjournal.bsky.social
- transcriptional cofactors don’t just help in gene activation, they also help guide their partner transcription factors to target genes academic.oup.com/nar/article/... ##zincfingers #chromatin #epigenetics #KLF
Nucleic Acids Research (@narjournal.bsky.social)
Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins inv...
narjournal.bsky.social
October 1, 2025 at 6:42 AM
Our latest paper, my 9th in one of my favourite journals
@narjournal.bsky.social
- transcriptional cofactors don’t just help in gene activation, they also help guide their partner transcription factors to target genes academic.oup.com/nar/article/... ##zincfingers #chromatin #epigenetics #KLF
@narjournal.bsky.social
- transcriptional cofactors don’t just help in gene activation, they also help guide their partner transcription factors to target genes academic.oup.com/nar/article/... ##zincfingers #chromatin #epigenetics #KLF
Reposted by Manan Shah
www.nature.com/articles/s41...
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Removal of promoter CpG methylation by epigenome editing reverses HBG silencing - Nature Communications
DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening...
www.nature.com
September 14, 2025 at 1:30 AM
www.nature.com/articles/s41...
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Reposted by Manan Shah
SMYD5 is a ribosomal methyltransferase that trimethylates RPL40 lysine 22 through recognition of a KXY motif
SMYD5 is a ribosomal methyltransferase that trimethylates RPL40 lysine 22 through recognition of a KXY motif
The human ribosome is highly modified by protein methylation. Here, Hamey et al. discover SMYD5 as the methyltransferase responsible for trimethylating ribosomal protein RPL40 at lysine 22. Systematic analysis of SMYD5 substrate recognition shows that it targets a KXY motif in RPL40, strongly suggesting that it is not a histone methyltransferase.
dlvr.it
April 6, 2025 at 11:23 PM
SMYD5 is a ribosomal methyltransferase that trimethylates RPL40 lysine 22 through recognition of a KXY motif
Reposted by Manan Shah
Next up at #LorneGenome25 we’ve got the second of the concurrrent sessions. I’m in session 8A - Gene Expression & Epigenetics, listening to @mananshah.bsky.social presenting his research on how transcription factors find their targets in vivo. I’m sure those in 8B are enjoying equally great science!
February 18, 2025 at 12:23 AM
Next up at #LorneGenome25 we’ve got the second of the concurrrent sessions. I’m in session 8A - Gene Expression & Epigenetics, listening to @mananshah.bsky.social presenting his research on how transcription factors find their targets in vivo. I’m sure those in 8B are enjoying equally great science!