This is a blebbing cancer cell in interphase. High levels of contractile force particularly in the cell's cortex can cause membrane blebbing outside of the the context of apoptosis. It happens in dividing cells during cytokinesis and in some metastatic cancer cells. #CellBiology

Yes. iPSC-derived cardiac myocytes do binucleate in culture; most if not all do it through aborted cytokinesis.

Yes. They can bleb-based migration, except that they typically need to be 3D environments. Bleb-based migration is not an efficient mode of migration on stiff 2D surfaces (e.g., glass).

This video shows an iPSC-derived cardiac myocyte videoed by Burnette Lab graduate student Emma Koory. Muscle myosin II is shown. #CellBiology

Grant reviewers hate the uncertainty that word implies; "What if they just take a bunch of videos with their microscopes?" Well, we would do that....... and some other stuff...... the idea that we would not discover something new along the way is laughable. The "other stuff" would be pretty cool.

Could we use these rare cells to uncover mechanisms underlying arrhythmias? Probably, but the way the Burnette Lab would approach that would require a lot of description-- I apologize for using such filthy language. Description indeed......

Yep! Too much laser!

Dylan Burnette (10th) @mag2art.bsky.social

This is an iPSC-cardiac myocyte, and they can still beat during mitosis. Does this happen in vivo or is it just a cell culture thing? I do not know.

Scam site or not, it is stealing my intellectual property. It is not OK to take people's art (no matter how that art is generated) and sell it.