Madison Martin
@madisonmartin.bsky.social
Neuroscience PhD candidate in the Bruchas lab @UW studying LC function in avoidance behavior 🧠🔬 #firstgen
Reposted by Madison Martin
Beyond happy & proud to have our paper on peptidergic neuromodulation of the #LC out!
This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵
www.science.org/doi/10.1126/...
This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵
www.science.org/doi/10.1126/...
Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety
Endogenous neuropeptide Y signaling modulates locus coeruleus activity, promoting adaptive responses to stress.
www.science.org
July 23, 2025 at 9:03 PM
Beyond happy & proud to have our paper on peptidergic neuromodulation of the #LC out!
This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵
www.science.org/doi/10.1126/...
This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵
www.science.org/doi/10.1126/...
Reposted by Madison Martin
Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal
Opioid withdrawal produces a dysphoric state that can lead to relapse. Simon et al.
reveal that lateral septal neurotensin-expressing neurons are selectively activated
by naloxone and drive changes in...
www.cell.com
May 16, 2025 at 3:39 PM
Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Madison Martin
Far from being a passive neighbor to the locus coeruleus, the pericoeruleus appears to act as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons, writes @macshine.bsky.social.
#neuroskyence
www.thetransmitter.org/attention/th...
#neuroskyence
www.thetransmitter.org/attention/th...
The brain’s quiet conductor: How hidden cells fine-tune arousal
New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the…
www.thetransmitter.org
May 7, 2025 at 3:47 PM
Far from being a passive neighbor to the locus coeruleus, the pericoeruleus appears to act as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons, writes @macshine.bsky.social.
#neuroskyence
www.thetransmitter.org/attention/th...
#neuroskyence
www.thetransmitter.org/attention/th...
Reposted by Madison Martin
We’ve been working on this project for several years and it’s finally out on bioarxiv! Check out the anatomical organization of the lateral septum and its connectivity
Lateral septum enthusiast? Interested in learning more about how LS projection populations and their inputs are organized. Check out our preprint in which @jennisisaac.bsky.social and @soniakarkare.bsky.social map out brain wide inputs to 6 LS projection populations. www.biorxiv.org/content/10.1...
Organization of brainwide inputs to discrete lateral septum projection populations
The lateral septum (LS) is anatomically positioned to play a critical role in directing information from the hippocampus and cortex to downstream subcortical structures, such as the hypothalamus. In f...
www.biorxiv.org
April 29, 2025 at 4:38 PM
We’ve been working on this project for several years and it’s finally out on bioarxiv! Check out the anatomical organization of the lateral septum and its connectivity
Reposted by Madison Martin
My first author paper is officially out!! Thank you to all of my co-authors for their help & support. So proud of the final product 😄😄
Pleased to share the final published version of @glopez.bsky.social's work in @currentbiology.bsky.social! www.sciencedirect.com/science/arti...
"Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning"
Congrats, Gaby!!!
"Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning"
Congrats, Gaby!!!
Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning
Avoidance learning—learning to avoid bad outcomes—is an essential survival behavior. Dopamine signals are widely observed in response to aversive stim…
www.sciencedirect.com
April 22, 2025 at 4:33 PM
My first author paper is officially out!! Thank you to all of my co-authors for their help & support. So proud of the final product 😄😄
Reposted by Madison Martin
I’m excited to share the most recent study from the Bruchas
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!
www.biorxiv.org/content/10.1...
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!
www.biorxiv.org/content/10.1...
Endocannabinoids facilitate transitory reward engagement through retrograde gain-control
Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory f...
www.biorxiv.org
January 10, 2025 at 5:41 PM
I’m excited to share the most recent study from the Bruchas
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!
www.biorxiv.org/content/10.1...
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!
www.biorxiv.org/content/10.1...
Reposted by Madison Martin
As I board my flight home for the holidays, I wanted to share that a review I wrote with @talialerner.bsky.social just came out! It’s titled “How dopamine enables learning from aversion.” Super grateful for the opportunity - hope you can check it out! 😊😊🎄🎄
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
How dopamine enables learning from aversion
Dopamine is heavily studied for its role in reward learning, but it is becoming increasingly appreciated that dopamine can also enable learning from a…
www.sciencedirect.com
December 22, 2024 at 6:59 PM
As I board my flight home for the holidays, I wanted to share that a review I wrote with @talialerner.bsky.social just came out! It’s titled “How dopamine enables learning from aversion.” Super grateful for the opportunity - hope you can check it out! 😊😊🎄🎄
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...