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@macjamil.bsky.social
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macjamil.bsky.social
www.nature.com/articles/d41...
How to make America healthy: the real problems — and best fixes
The United States has lower life expectancy than most similarly wealthy nations. Chronic disease is part of the cause, but so are guns, drugs and cars.
www.nature.com
June 24, 2025 at 1:04 PM
macjamil.bsky.social
www.nature.com/articles/s41...
The next generation of immunotherapies for lung cancers - Nature Reviews Clinical Oncology
Immune-checkpoint inhibitors (ICIs) have improved lung cancer outcomes, although resistance to these agents presents a substantial challenge. This Review describes the progress made in developing the ...
www.nature.com
June 18, 2025 at 1:57 AM
macjamil.bsky.social
www.newyorker.com/magazine/202...
The Catch in Catching Cancer Early
New blood tests promise to detect malignancies before they’ve spread. But proving that these tests actually improve outcomes remains a stubborn challenge.
www.newyorker.com
June 17, 2025 at 12:56 AM
macjamil.bsky.social
www.nature.com/articles/d41...
World first: brain implant lets man speak with expression — and sing
Device translates thought to speech in real time.
www.nature.com
June 12, 2025 at 6:04 PM
macjamil.bsky.social
www.ahajournals.org/doi/10.1161/...
Alcohol Use and Cardiovascular Disease: A Scientific Statement From the American Heart Association | Circulation
Alcohol is one of the most commonly consumed substances in the world, exhibiting complex relationships with multiple aspects of cardiovascular health and disease. The majority of the research on the t...
www.ahajournals.org
June 10, 2025 at 12:05 PM
macjamil.bsky.social
jamanetwork.com/journals/jam...
Overall Survival and Quality-of-Life Superiority in Modern Phase 3 Oncology Trials
This meta-epidemiological study analyzes phase 3 oncology randomized clinical trials to determine the proportions of trials that show improvement in overall survival, quality of life, and alternative ...
jamanetwork.com
June 5, 2025 at 2:01 AM
macjamil.bsky.social
www.nature.com/articles/d41...
Brain drugs can now cross the once impenetrable blood–brain barrier
New technologies to shuttle drugs into the brain are showing promise in Alzheimer’s disease, cancer and more.
www.nature.com
May 28, 2025 at 2:51 PM
macjamil.bsky.social
www.thelancet.com/journals/lan...
FaceAge, a deep learning system to estimate biological age from face photographs to improve prognostication: a model development and validation study
Our results suggest that a deep learning model can estimate biological age from face photographs and thereby enhance survival prediction in patients with cancer. Further research, including validation...
www.thelancet.com
May 9, 2025 at 11:58 AM
macjamil.bsky.social
www.science.org/doi/10.1126/...
Imaging-guided deep tissue in vivo sound printing
Three-dimensional printing offers promise for patient-specific implants and therapies but is often limited by the need for invasive surgical procedures. To address this, we developed an imaging-guided...
www.science.org
May 8, 2025 at 11:21 PM
macjamil.bsky.social
www.nature.com/articles/s41...
Improving outcomes of patients with pancreatic cancer - Nature Reviews Clinical Oncology
The incidence of pancreatic ductal adenocarcinoma (PDAC) has been increasing over the past few decades and survival rates for patients with this malignancy remain dismal. The authors of this Perspecti...
www.nature.com
May 7, 2025 at 11:19 AM
macjamil.bsky.social
www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
www.nature.com
May 3, 2025 at 8:18 PM
macjamil.bsky.social
www.thelancet.com/journals/lan...
Gastric cancer
Gastric cancer remains a major health challenge worldwide, with nearly 1 million new cases annually contributing to more than 650 000 deaths. Epidemiologically, gastric cancer shows substantial geogra...
www.thelancet.com
May 2, 2025 at 2:01 PM
macjamil.bsky.social
bjsm.bmj.com/content/earl...
Impact of exercise on health outcomes in people with cancer: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials
Objective To examine the comprehensive health impacts of exercise on people with cancer by systematically summarising existing evidence and assessing the strength and reliability of the associations. ...
bjsm.bmj.com
April 30, 2025 at 12:02 AM
macjamil.bsky.social
www.nejm.org/doi/full/10....
Routine Surveillance for Cancer Metastases — Does It Help or Harm Patients? | NEJM
Research generally suggests that routine surveillance after cancer treatment finds more recurrences — leading to more surgery, chemotherapy, and radiation — without affecting the risk of death.
www.nejm.org
April 27, 2025 at 11:04 PM
macjamil.bsky.social
www.nature.com/articles/s41...
Geographic and age variations in mutational processes in colorectal cancer - Nature
Nature - Geographic and age variations in mutational processes in colorectal cancer
www.nature.com
April 24, 2025 at 11:28 AM
macjamil.bsky.social
variety.com/2025/tv/news...
Stephen Frears Tapped to Helm ‘The Anarchy’ Series for Wiip, Roy Kapur Films (EXCLUSIVE)
Stephen Frears will direct the television adaptation of William Dalrymple's bestseller 'The Anarchy' for Wiip and India's Roy Kapur Films.
variety.com
April 24, 2025 at 1:21 AM
macjamil.bsky.social
www.sciencedirect.com/science/arti...
KRAS G12C Inhibitors as Monotherapy or in Combination for Metastatic Colorectal Cancer: A Proportion and Comparative Meta-Analysis of Efficacy and Toxicity from Phase I-II-III Trials
1-2% of metastatic colorectal cancers (mCRC) harbor an activating KRAS-G12C mutation. This study aims to pool the results of available clinical trials…
www.sciencedirect.com
April 23, 2025 at 1:30 PM
macjamil.bsky.social
www.nature.com/articles/s41...
Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors - Nature Communications
The aging immune system is characterized by changes in immune cell frequencies and functionality. Here the authors report dynamics of age-related divergence of circulating immune responses in patients...
www.nature.com
April 22, 2025 at 9:27 PM
macjamil.bsky.social
www.nature.com/articles/s41...
Evolutionary paths towards metastasis - Nature Reviews Cancer
In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insigh...
www.nature.com
April 22, 2025 at 3:22 PM
macjamil.bsky.social
seer.cancer.gov/report_to_na...
Annual Report to the Nation 2025 National Cancer Statistics
The Annual Report to the Nation on the Status of Cancer has statistics on cancer deaths and new cases (incidence).
seer.cancer.gov
April 22, 2025 at 12:49 AM
macjamil.bsky.social
April 22, 2025 at 12:32 AM
macjamil.bsky.social
www.nature.com/articles/s41...
Spotlight on cancer immunotherapies - Nature Biotechnology
Advances in cancer immunotherapy have shown promising results for treatment of tumors, yet challenges related to therapeutic efficacy and manufacturing processes need to be overcome.
www.nature.com
April 21, 2025 at 11:33 AM
macjamil.bsky.social
www.thelancet.com/journals/lan...
Pancreatic cancer
Pancreatic cancer is frequently a lethal disease with an aggressive tumour biology often presenting with non-specific symptoms. Median survival is approximately 4 months with a 5-year survival of 13%....
www.thelancet.com
April 21, 2025 at 1:22 AM
macjamil.bsky.social
www.researchsquare.com/article/rs-5...
Antibody-mediated co-delivery of programmable drug combinations
Drug combinations often fail in clinic due to poor disease site tropism and additive toxicities1,2. Targeted delivery by antibody-drug conjugates (ADCs) reduces toxicity for single chemotherapeutic pa...
www.researchsquare.com
April 19, 2025 at 9:49 PM
macjamil.bsky.social
www.nature.com/articles/s41...
Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic b...
npj Breast Cancer - Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients...
www.nature.com
April 16, 2025 at 6:22 PM