John Lukens
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lukensjohnr.bsky.social
John Lukens
@lukensjohnr.bsky.social
Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.
www.lukenslab.com
Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...
August 6, 2025 at 1:40 PM
Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...
August 4, 2025 at 1:54 PM
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
www.nature.com/articles/s41...
July 16, 2025 at 1:45 PM
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
July 14, 2025 at 3:46 PM
Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...
July 11, 2025 at 4:26 PM
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...
July 10, 2025 at 6:58 PM
Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...
July 5, 2025 at 4:33 PM
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 23, 2025 at 8:07 PM
Peripheral infection wires T cells in the brain
www.nature.com/articles/s41...
June 18, 2025 at 1:01 PM
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 16, 2025 at 2:33 PM
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
June 13, 2025 at 1:27 PM
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
June 9, 2025 at 9:13 PM
CLEC7A/Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 9, 2025 at 4:54 PM
Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
June 4, 2025 at 2:59 PM
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
June 3, 2025 at 2:49 PM
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 30, 2025 at 3:38 PM
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 19, 2025 at 3:14 PM
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...
May 15, 2025 at 10:57 AM
B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine www.nature.com/articles/s41...
April 22, 2025 at 2:01 PM
ILC2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
April 14, 2025 at 4:23 PM
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease @nature.com
www.nature.com/articles/s41...
April 9, 2025 at 4:08 PM
Microglia are such a pain.
www.nature.com/articles/s41...
April 9, 2025 at 3:38 PM
April 8, 2025 at 2:37 PM
Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...
April 7, 2025 at 2:42 PM
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB: @cellpress.bsky.social www.cell.com/cell/fulltex...
April 7, 2025 at 2:39 PM