John Lukens
@lukensjohnr.bsky.social
Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.
www.lukenslab.com
www.lukenslab.com
Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...
August 6, 2025 at 1:40 PM
Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...
Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...
August 4, 2025 at 1:54 PM
Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 16, 2025 at 1:45 PM
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 14, 2025 at 3:46 PM
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...
July 11, 2025 at 4:26 PM
Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...
July 10, 2025 at 6:58 PM
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...
Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...
July 5, 2025 at 4:33 PM
Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 23, 2025 at 8:07 PM
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
Peripheral infection wires T cells in the brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 18, 2025 at 1:01 PM
Peripheral infection wires T cells in the brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 16, 2025 at 2:33 PM
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 13, 2025 at 1:27 PM
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
www.aai.org/Education/Co...
June 9, 2025 at 9:13 PM
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
www.aai.org/Education/Co...
CLEC7A/Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 9, 2025 at 4:54 PM
CLEC7A/Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis @cp-immunity.bsky.social www.cell.com/immunity/ful...
Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
June 4, 2025 at 2:59 PM
Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
June 3, 2025 at 2:49 PM
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 30, 2025 at 3:38 PM
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 19, 2025 at 3:14 PM
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...
May 15, 2025 at 10:57 AM
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...
B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine www.nature.com/articles/s41...
April 22, 2025 at 2:01 PM
B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine www.nature.com/articles/s41...
ILC2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
April 14, 2025 at 4:23 PM
ILC2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 4:08 PM
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglia are such a pain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 3:38 PM
Microglia are such a pain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glia get RIPped in ALS. @cp-immunity.bsky.social www.cell.com/immunity/ful...
April 8, 2025 at 2:37 PM
Glia get RIPped in ALS. @cp-immunity.bsky.social www.cell.com/immunity/ful...
Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...
April 7, 2025 at 2:42 PM
Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB: @cellpress.bsky.social www.cell.com/cell/fulltex...
April 7, 2025 at 2:39 PM
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB: @cellpress.bsky.social www.cell.com/cell/fulltex...