Lucile Noyer
@lucilenoyer.bsky.social
Postdoc @ NYUGSoM studying transporters in immune cells #autoimmunity #immunometabolism #cancer
Pinned
Lucile Noyer
@lucilenoyer.bsky.social
· Jul 17
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
doi.org
I’m excited to share our new paper published in #Sience #Immunology ! We show that CLNS1A is essential for #CD4 #TCell and #Autoimmunity
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
Reposted by Lucile Noyer
Noyer, @stefanfeske.bsky.social et al show that a novel mutation in ORAI1 results in constitutive CRAC channel activation while abolishing stimulation-induced channel opening. The mutation is associated with severe immune dysregulation, incl. altered T & NK cell function rupress.org/jhi/article/...
October 30, 2025 at 4:45 PM
Noyer, @stefanfeske.bsky.social et al show that a novel mutation in ORAI1 results in constitutive CRAC channel activation while abolishing stimulation-induced channel opening. The mutation is associated with severe immune dysregulation, incl. altered T & NK cell function rupress.org/jhi/article/...
I’m excited to share our new paper published in #Sience #Immunology ! We show that CLNS1A is essential for #CD4 #TCell and #Autoimmunity
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
doi.org
July 17, 2025 at 3:27 PM
I’m excited to share our new paper published in #Sience #Immunology ! We show that CLNS1A is essential for #CD4 #TCell and #Autoimmunity
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
Reposted by Lucile Noyer
Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
www.science.org
June 20, 2025 at 6:34 PM
Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!
Reposted by Lucile Noyer
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells @sciimmunology.bsky.social @NoyerLucile @stefanfeske.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 20, 2025 at 6:56 PM
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells @sciimmunology.bsky.social @NoyerLucile @stefanfeske.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...