Lucas E. Sant'Anna
@lucasesantanna.bsky.social
Bioengineering PhD Candidate at Stanford
Studying synthetic biology 🧬 immune cell engineering 🦠 and mathematical modeling 🧮
Check out my Google Scholar! https://scholar.google.com/citations?user=HzNBI8oAAAAJ&hl=en
Studying synthetic biology 🧬 immune cell engineering 🦠 and mathematical modeling 🧮
Check out my Google Scholar! https://scholar.google.com/citations?user=HzNBI8oAAAAJ&hl=en
Go check out the new preprint from the Daniels Lab! It's been so exciting to see this project evolve 🧪💯
🚨 New Preprint 🚨
A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
How can we tune JAK/STAT signaling to create better immune cell therapies?
doi.org/10.1101/2025.0…
A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
How can we tune JAK/STAT signaling to create better immune cell therapies?
doi.org/10.1101/2025.0…
June 9, 2025 at 6:45 PM
Go check out the new preprint from the Daniels Lab! It's been so exciting to see this project evolve 🧪💯
Reposted by Lucas E. Sant'Anna
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Engineering synthetic phosphorylation signaling networks in human cells
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...
science.org
January 7, 2025 at 8:24 AM
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Paper alert! Really grateful to be part of this project with Dr. Xiaojing Gao engineering cytokine secretion with humanized proteases. www.nature.com/articles/s41...
Orthogonalized human protease control of secreted signals - Nature Chemical Biology
Engineering of a human-derived protease controlled exogenously by its FDA-approved inhibitor enables control over cytokine activity in cell-based therapies with reduced risk of immunogenicity.
www.nature.com
January 21, 2025 at 10:33 PM
Paper alert! Really grateful to be part of this project with Dr. Xiaojing Gao engineering cytokine secretion with humanized proteases. www.nature.com/articles/s41...