Lucas A. Defelipe
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lucasdefelipe.bsky.social
Lucas A. Defelipe
@lucasdefelipe.bsky.social
110 followers 260 following 1 posts
Senior technical officer @ EMBL Hamburg. Biophysics and Structural Biology
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Reposted by Lucas A. Defelipe
spcembl.bsky.social
🔊 Thrilled to share our latest work, just published in NAR! 📃

We present ChiraKit, open-source tool to process raw CD data and perform advanced analysis!

Access via our eSPC web-server!

➡️ spc.embl-hamburg.de
@osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social
April 28, 2025 at 9:24 AM
Reposted by Lucas A. Defelipe
spcembl.bsky.social
🔊 Our latest biophysical tool for circular dichroism analysis, ChiraKit, is out 🔍

To read more about it, visit www.biorxiv.org/content/10.1...

ChiraKit can be accessed at spc.embl-hamburg.de

@osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social
@mosbri.bsky.social
January 31, 2025 at 9:52 AM
Reposted by Lucas A. Defelipe
osvalb.bsky.social
Just out! 🥳🥳 Great work done at the @spcembl.bsky.social to understand clathrin-mediated endocytosis. We investigated how clathrin and adaptor proteins interact in vitro and in vivo. Kudos to the 1st author @lucasdefelipe.bsky.social!

www.nature.com/articles/s41...

www.embl.org/news/science...
November 18, 2024 at 9:30 AM
Reposted by Lucas A. Defelipe
spcembl.bsky.social
New preprint alert 🔔 !

New insights into the clathrin-mediated endocytosis machinery!

Sla2 emerges as a central hub interacting with Clathrin Light Chains and the Pan1/End3/Sla1 complex.

Read the full study:

doi.org/10.1101/2024...

#embl @cssbhamburg.bsky.social @lucasdefelipe.bsky.social
Sla2 is a core interaction hub for Clathrin Light Chain and the Pan1/End3/Sla1 Complex
The interaction network of Sla2, a vital adaptor protein in the endocytic mid-coat, undergoes constant rearrangement incorporating or replacing interacting proteins over time. Sla2 serves as a scaffol...
doi.org
November 18, 2024 at 9:06 AM