Takotsubo syndrome (TTS) is an acute heart failure syndrome characterized by a transient impairment of systolic function [1]. Adverse outcomes have been described both in the acute phase and, despite the recovery of left ventricular ejection fraction (LVEF), in the long-term, with rates comparable to those observed in acute myocardial infarction (AMI) [2–5]. Though a full understanding of its pathophysiology is currently lacking, a central role seems to be played by increased adrenergic drive at cardiac level [6], coupled with a predisposed background including, among others, advanced age [7], female sex [8] and the presence of emotional and physical preceding triggers [9].