Phil Drewniak
@lostmydeuteron.bsky.social
Protein dynamics, structural biology, genetic code expansion, and isotopically labelled amino acid synthesis.
🇨🇦🇨🇦
PhD student | University of Toronto | Biological chemistry
#ChemSky #ProteinCosmo
🇨🇦🇨🇦
PhD student | University of Toronto | Biological chemistry
#ChemSky #ProteinCosmo
Even more interestingly, I did find this paper, where 2,6-diaminopirine (dZTP)completely substitutes for adenine in some bacteriophage genomes, which is really interesting:
pubmed.ncbi.nlm.nih.gov/38042029/
pubmed.ncbi.nlm.nih.gov/38042029/
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system - PubMed
Oxidative damage is a major source of genomic instability in all organisms with the aerobic metabolism. 8-Oxoguanine (8-oxoG), an abundant oxidized purine, is mutagenic and must be controlled by a ded...
pubmed.ncbi.nlm.nih.gov
February 16, 2025 at 8:14 PM
Even more interestingly, I did find this paper, where 2,6-diaminopirine (dZTP)completely substitutes for adenine in some bacteriophage genomes, which is really interesting:
pubmed.ncbi.nlm.nih.gov/38042029/
pubmed.ncbi.nlm.nih.gov/38042029/
Could also be thinking of DNA methylation, the methylated analogies of the ATCG nucleotides, 5-methyl cytosine etc.
Also products of oxidation, such as 8-oxo-guanine exist
Also products of oxidation, such as 8-oxo-guanine exist
February 16, 2025 at 8:11 PM
Could also be thinking of DNA methylation, the methylated analogies of the ATCG nucleotides, 5-methyl cytosine etc.
Also products of oxidation, such as 8-oxo-guanine exist
Also products of oxidation, such as 8-oxo-guanine exist
Typically the canonical nucleotides are just those, ACTG and U. You may be thinking of some non-canonical nucleotide, but those aren’t used in DNA, least not on this world.
Some of those non-canonicals may be used in other facets of metabolism though…
Some of those non-canonicals may be used in other facets of metabolism though…
February 16, 2025 at 8:08 PM
Typically the canonical nucleotides are just those, ACTG and U. You may be thinking of some non-canonical nucleotide, but those aren’t used in DNA, least not on this world.
Some of those non-canonicals may be used in other facets of metabolism though…
Some of those non-canonicals may be used in other facets of metabolism though…
Reposted by Phil Drewniak
On the bright side about fire ant venom:
'Derivatives of solenopsins, (fire ant potent piperidine alkaloids), have been found to have antibacterial, antifungal, insecticidal, and antiangiogenics activities'
(article about the Thai fire ant Solenopsis geminata)
pmc.ncbi.nlm.nih.gov/articles/PMC...
'Derivatives of solenopsins, (fire ant potent piperidine alkaloids), have been found to have antibacterial, antifungal, insecticidal, and antiangiogenics activities'
(article about the Thai fire ant Solenopsis geminata)
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 29, 2024 at 1:14 AM
On the bright side about fire ant venom:
'Derivatives of solenopsins, (fire ant potent piperidine alkaloids), have been found to have antibacterial, antifungal, insecticidal, and antiangiogenics activities'
(article about the Thai fire ant Solenopsis geminata)
pmc.ncbi.nlm.nih.gov/articles/PMC...
'Derivatives of solenopsins, (fire ant potent piperidine alkaloids), have been found to have antibacterial, antifungal, insecticidal, and antiangiogenics activities'
(article about the Thai fire ant Solenopsis geminata)
pmc.ncbi.nlm.nih.gov/articles/PMC...