Our case report of a patient developing drug-induced systemic sclerosis after bleomycin exposure – still showing antibodies after 5 years. Nicely done Philipp 🎉 #rheumsky

authors.elsevier.com/sd/article/S...

induction of a proinflammatory myeloid cell state. These produce tissue-damaging proteases like MMP9 and CXCR3 ligands thereby recruiting even more inflammatory cells.

First manuscript of my postdoc at @mgbresearch.bsky.social and a great teamwork with Alvin, Sophia, Kevin, Shruti and all others

The strongest transcriptional signal in ICI-AIN is a IFNg response signature. Interestingly, the IFNg is mostly produced by CD8 T cells that have a more exhausted/tissue-resident phenotype.
Likely consequences of IFNg include reduced OxPhos in tubules and ... 4/n

We identify different types of immune infiltrates that are structured by different chemokine/receptor axes: Infiltrates with proinflammatory myeloid cells show strong CXCR3/CXCL9+10+11 signalling, while tertiary lymphoid structures show stronger CXCR5/CXCL13 signaling. 3/n

Using the Xenium 5K panel, we used the tessera package to define cellular neighbourhoods. These nicely correspond to the different parts of the nephron, but also show (unsurprisingly) immune cell infiltration. 2/n

What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.

www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪

So proud of these guys. Amazing final game, the turkish team played impressive basketball, but in the end we prevailed 🔥🏀

Was ne Mannschaft! 🔥🏀

In Lupus nephritis patients, neutrophils have increased surface LAMP1, which is externalized after activation. Soluble LAMP1 is increased both in the blood and urine of patients, correlating with histological activity. #NephSky 🧪
Our paper in @eurjimmunol.bsky.social
doi.org/10.1002/eji....

Dimi @dlwagner.bsky.social showing how TruC edited Tregs have superior properties compared to CAR-Tregs for use in cell therapy. #FOCIS2025 🧪

Deepak Rao receives the Lupus Insight Award at the #FOCIS2025 following his insights on the IFN-induced dysbalance of Tph and Th22 cells in SLE. 🎉🧪

First fruit of my postdoc in the Rao lab:
Our "Nephrology Digest" article on the roles of ILCs, GM-CSF and disease-associated macrophages in lupus nephritis @kidneyint.bsky.social
authors.elsevier.com/a/1k-ypJOcpz...

#NephSky #ImmunoSky 🧪

This is a scandal!
#immunoSky 🧪

Preprint from the Rao lab: CD57+ Tem CD8 cells are associated with interstitial lung disease in Systemic Sclerosis. One mechanism seems to be co-stimulatory CD226 interacting with CD155 on damaged epithelial cells.
Sasaki et al 2025 on
www.biorxiv.org/content/10.1...

Christmas #FluorescenceFriday
Glomerular IgG Deposition in a Lupus Nephritis kidney biopsy.

Harshan Singh Bhati showing how completely cleared DISCO mice and human organs can be used to identify unrecognized metastases and to combine with mass spectrometry for 3D targeted proteomics. #ESSB2024
see www.cell.com/cell/fulltex...

Day 2 #ESSB2024
Aysegül Adam from the lab of Anja Hauser presents multiplex histology data showing activated ILC1 localisation in human periodontitis and their fibrovascular niches.

Excellent talks at the European Society of Spatial Biology Meeting in Berlin! Leeat Keren @leeat-keren.bsky.social presents CellTune as a new "query by committee" solution for cell annotation in spatial protein data 🔥