Long-Hung Pham
@longhung-pham.bsky.social
PhD student in computational Chemical Biology at Imperial College London
Reposted by Long-Hung Pham
🚀 Our new Science paper is out (w/ B DeMeo, D Burkhardt, A Shalek, M Cortes): www.science.org/doi/10.1126/...
We show that active learning + transcriptomic perturbations can guide which exps to run next, boosting phenotypic hit rates >13x. AI not just predicting bio, but designing it. 🔁
We show that active learning + transcriptomic perturbations can guide which exps to run next, boosting phenotypic hit rates >13x. AI not just predicting bio, but designing it. 🔁
October 25, 2025 at 1:24 PM
🚀 Our new Science paper is out (w/ B DeMeo, D Burkhardt, A Shalek, M Cortes): www.science.org/doi/10.1126/...
We show that active learning + transcriptomic perturbations can guide which exps to run next, boosting phenotypic hit rates >13x. AI not just predicting bio, but designing it. 🔁
We show that active learning + transcriptomic perturbations can guide which exps to run next, boosting phenotypic hit rates >13x. AI not just predicting bio, but designing it. 🔁
Reposted by Long-Hung Pham
New @biorxiv-biophys.bsky.social preprint from the #keedylab! 👀
www.biorxiv.org/content/10.1...
How do related proteins perform distinct functions despite sharing a similar structure?...
www.biorxiv.org/content/10.1...
How do related proteins perform distinct functions despite sharing a similar structure?...
Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models
How do related proteins with a common fold perform diverse biological functions? Although the average structure may be similar, structural excursions from this average may differ, giving rise to allos...
www.biorxiv.org
May 27, 2025 at 7:23 PM
New @biorxiv-biophys.bsky.social preprint from the #keedylab! 👀
www.biorxiv.org/content/10.1...
How do related proteins perform distinct functions despite sharing a similar structure?...
www.biorxiv.org/content/10.1...
How do related proteins perform distinct functions despite sharing a similar structure?...
Reposted by Long-Hung Pham
It is always best to get scooped on a project before you put much work on it. Really cool preprint by Taylor Mighell and Ben Lehner on the effect of binder molecules on general rescue effect of destabilizing variants. Should work with protein binders as well. www.biorxiv.org/content/10.1...
www.biorxiv.org
December 3, 2024 at 9:18 AM
It is always best to get scooped on a project before you put much work on it. Really cool preprint by Taylor Mighell and Ben Lehner on the effect of binder molecules on general rescue effect of destabilizing variants. Should work with protein binders as well. www.biorxiv.org/content/10.1...
Reposted by Long-Hung Pham
