LongCovidPharmD
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longcovidpharmd.bsky.social
LongCovidPharmD
@longcovidpharmd.bsky.social
980 followers 430 following 13 posts
Pharmacist interested in Long COVID and ME/CFS research
Pro-mask, pro-clean air!
Substack: https://pharmd.substack.com/
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longcovidpharmd.bsky.social
Soon I'll post another spreadsheet showing individual treatment effects on specific symptoms (~30 different symptoms). A few example charts from preliminary data are shown here w/ alt text.
Top 20 patient-reported treatments (from 100+ treatments surveyed) for fast, fluttering or pounding heart. Cardioselective beta blockers and ivabradine show similar efficacy, whereas propranolol exhibits slightly lower efficacy and tolerability. Examples of cardiovascular beta blockers = atenolol, bisoprolol, metoprolol, nebivolol. While higher doses of EPA can induce atrial fibrillation, in this survey over a wider range of doses, EPA was well-tolerated. Fast, fluttering or pounding heart (Bottom 10 treatments) -- shows the bottom 10 treatments for this symptom: fluvoxamine, SNRIs, CBT, corticosteroids, green tea, amitriptyline & other TCAs, matcha tea, black tea, (ar)modafinil, and ADHD stimulants. ADHD stimulants worsened fast, fluttering or pounding heart in ~48% of patients who rated it and reportedly improved this symptom in ~7%, yielding a net effectiveness score of -41%. Symptoms are organized by effectiveness Top 30 patient-reported treatments (from 100+ treatments surveyed) for fatigue. Unsurprisingly, ADHD stimulants helped to the greatest degree, followed by armodafinil & modafinil, IVIG &subQ IgG, oxaloacetate. nattokinase/lumbrokinase and thiamine. It is interesting to note how well the latter three supplements performed considering their accessiblity and relative safety compared to something like IVIG which is incredibly difficult to access or ADHD stimulants which are strictly controlled. Info on dosing & brands used for NK/LK has been discussed previously. Most who rated oxaloacetate used one specific brand & higher doses to be discussed in depth later. Low-dose Abilify (aripiprazole) looks promising for fatigue despite other data for Overall Condition showing lower tolerability. LDN's results were less robust, with fatigue improving in just under 50% of those who trialed the medication and experienced fatigue. Matcha tea was considerably more effective than green tea likely in part due to the higher caffeine content in the former.
January 20, 2025 at 5:07 AM