Liz Balint
@lizbalint.bsky.social
PhD candidate at McMaster University studying #neuroimmunology and #Zika infection
Happy to share that my latest work was published in European Journal of Immunology!
We find that male CD8+ T cells show greater bystander activation and cytotoxicity compared to T cells from female donors, which could explain why males show greater disease severity during acute viral infections.
We find that male CD8+ T cells show greater bystander activation and cytotoxicity compared to T cells from female donors, which could explain why males show greater disease severity during acute viral infections.
'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
Biological Sex Influences Human Bystander CD8+ T Cell Activation
CD8+ T cells isolated from male donors exhibit greater IL-15–driven bystander activation, NKG2D expression, and cytotoxicity than female CD8+ cells. This study reveals a sex-based difference in innat....
onlinelibrary.wiley.com
July 3, 2025 at 6:26 PM
Happy to share that my latest work was published in European Journal of Immunology!
We find that male CD8+ T cells show greater bystander activation and cytotoxicity compared to T cells from female donors, which could explain why males show greater disease severity during acute viral infections.
We find that male CD8+ T cells show greater bystander activation and cytotoxicity compared to T cells from female donors, which could explain why males show greater disease severity during acute viral infections.