Livia Piatti
@liviapiatti.bsky.social
Bioengineering | Neurobiology and Infection | @LifeArc Knowledge Transfer Innovation Fellow | @EMBL Alumna
Reposted by Livia Piatti
Today my main PHD project in the lab of Dr. Maria Bernabeu was published!
Using a 3D brain microvessel model, we show:
1) an unappreciated role of brain pericytes in cerebral malaria pathogenesis
2) Tie-2 activation by AKB-9778 as a potential therapeutic avenue
www.embopress.org/doi/full/10....
Using a 3D brain microvessel model, we show:
1) an unappreciated role of brain pericytes in cerebral malaria pathogenesis
2) Tie-2 activation by AKB-9778 as a potential therapeutic avenue
www.embopress.org/doi/full/10....
October 17, 2025 at 4:59 PM
Today my main PHD project in the lab of Dr. Maria Bernabeu was published!
Using a 3D brain microvessel model, we show:
1) an unappreciated role of brain pericytes in cerebral malaria pathogenesis
2) Tie-2 activation by AKB-9778 as a potential therapeutic avenue
www.embopress.org/doi/full/10....
Using a 3D brain microvessel model, we show:
1) an unappreciated role of brain pericytes in cerebral malaria pathogenesis
2) Tie-2 activation by AKB-9778 as a potential therapeutic avenue
www.embopress.org/doi/full/10....
Reposted by Livia Piatti
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier
Plasmodium falciparum accumulation at the blood-brain barrier (BBB) is a hallmark of cerebral malaria, a life-threatening complication. Conversely, the contribution of the immune response to vascular ...
www.biorxiv.org
October 21, 2025 at 11:06 AM
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Reposted by Livia Piatti
EMBL Barcelona researchers have created a lab-grown blood-brain barrier to show how the malaria parasite damages it, and have successfully tested potential therapeutics that could help prevent or even reverse the damage.
#tissuebiology
www.embl.org/news/science...
#tissuebiology
www.embl.org/news/science...
September 18, 2025 at 11:57 AM
EMBL Barcelona researchers have created a lab-grown blood-brain barrier to show how the malaria parasite damages it, and have successfully tested potential therapeutics that could help prevent or even reverse the damage.
#tissuebiology
www.embl.org/news/science...
#tissuebiology
www.embl.org/news/science...
Exciting to see our paper finally out ✨ Shoutout to my amazing co-first author @alinabatzi.bsky.social and group leader @mariabernabeu.bsky.social for these great years of working together. And a big thank you to everyone involved!
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
rdcu.be
August 7, 2025 at 11:39 AM
Exciting to see our paper finally out ✨ Shoutout to my amazing co-first author @alinabatzi.bsky.social and group leader @mariabernabeu.bsky.social for these great years of working together. And a big thank you to everyone involved!