The field of Infectious Diseases often requires collaboration across many disciplines within our specialty: internal medicine, pediatrics, obstetrics, public health, clinical microbiology, basic and translational researchers, regulatory agencies, and industry partners. The COVID-19 pandemic was a prolonged example of how each party participated in a coordinated response. The journals that are affiliated with the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society historically have operated independently to curate articles for an extensively overlapping readership. As the new Editors in Chief of Journal of Infectious Diseases (JID) and The Journal of the Pediatric Infectious Disease Society (JPIDS), we discussed how our journals could collaborate to bring high-quality articles to our readers on topics that bridged the traditional focus of each journal. As we consider the pathogenesis and clinical manifestations of infectious diseases between children and adults, there are more similarities than differences. However, the differences that do exist often are the result of key developmental and maturational factors that reveal insights about host–pathogen interactions. We are pleased to introduce the first fruits of collaboration between our 2 journals in a series of articles slated to appear in future issues over the next year on the topic of “Neurovirulence.”

Herpes simplex virus is a ubiquitous human pathogen that can rarely cause severe debilitating encephalitis. Accumulating data suggest subclinical infection