Linda Goodman
lindabgoodman.bsky.social
Linda Goodman
@lindabgoodman.bsky.social
Co-founder and Chief Technology Officer @FaunaBio
Unraveling genomic secrets in mammals to cure human diseases,
Alum @Harvard @BroadInstitute @Cambridge_Uni
What started as an effort to better understand heart failure for
Fauna Bio's HFpEF program turned into a surprising discovery about XIST, thanks to @goringennady.bsky.social's sharp thinking and fearless curiosity! 🚀
New preprint out!
This is probably my most important paper. To my deep chagrin, it has no math.
XIST is a non-coding RNA exclusive to XX females. It silences one of the X chromosomes.
So what is it doing in male heart Schwann cells?
Male XIST expression in cardiac pseudo-glia does not induce X chromosome inactivation https://www.biorxiv.org/content/10.1101/2025.04.09.648005v1
April 15, 2025 at 8:13 PM