I’d like to thank all the co authors, especially Caio Salgado who spearheaded this project, as well as my collaborator Dr. Fonseca. We hope this counterintuitive IL33 mediated effect can help explain at least some of the aspects of the so called “hygiene hypothesis”

In this work, we discovered that gut exposure to enterotoxigenic E. coli (the ones that cause travelers diarrhea 😬) or its heat labile toxin can protect mice from lung type 2 allergy, which is linked to lung ILC2s losing their function. Paradoxically, this effect occurs BECAUSE of gut IL33 release!