Lisa Gennai
lgennai.bsky.social
Lisa Gennai
@lgennai.bsky.social
PhD at EPFL | Biophysics and Machine Learning
Reposted by Lisa Gennai
Here we are, trying to teach an old, but always fantastic dog (Direct Coupling Analysis) some new tricks! It learns them pretty well.
Together with @fcaredda.bsky.social @lgennai.bsky.social and bluesky-absent Andrea Pagnani.

www.biorxiv.org/content/10.1...
Controllable Protein Design via Autoregressive Direct Coupling Analysis Conditioned on Principal Components
We present FeatureDCA, a statistical framework for protein sequence modeling and generation that extends Direct Coupling Analysis (DCA) with biologically meaningful conditioning. The method can levera...
www.biorxiv.org
August 22, 2025 at 3:34 PM