Lexi Rindone
@lexi-rindone.bsky.social
I'm a postdoc fellow @HopkinsMedicine focused on targeting senescent cells to promote MSK tissue regeneration! | PhD @JHUBME '22 | BS @RPI '15 | Outgoing @SyisTermis Chair | AZ Native 🌵
Had such an amazing time at #TERMIS2024! Thank you so much to co-chairs @nasimannabi & @cosgriffhernan for organizing such an extraordinary event! And, thank you to our fellow SYIS council members for all their efforts in leading our young investigator activities!
December 10, 2024 at 11:48 PM
Had such an amazing time at #TERMIS2024! Thank you so much to co-chairs @nasimannabi & @cosgriffhernan for organizing such an extraordinary event! And, thank you to our fellow SYIS council members for all their efforts in leading our young investigator activities!
Grateful for the opportunity to present my postdoc and PhD research at #TERMIS2023 on Thursday! Feel free to attend if you are interested in how aging impacts the biomaterial response, or in 3D bone imaging. Thank you @JHElisseeff and @GraysonLab for your amazing mentorship!
December 10, 2024 at 11:48 PM
Grateful for the opportunity to present my postdoc and PhD research at #TERMIS2023 on Thursday! Feel free to attend if you are interested in how aging impacts the biomaterial response, or in 3D bone imaging. Thank you @JHElisseeff and @GraysonLab for your amazing mentorship!
I said yes to my partner and best friend of 8.5 years this weekend! Excited to start this next chapter of our lives together!
December 10, 2024 at 11:48 PM
I said yes to my partner and best friend of 8.5 years this weekend! Excited to start this next chapter of our lives together!
If you're at @SFBiomaterials #SFB2022, I'll be presenting our @GraysonLab research using #tissueclearing & #lightsheet imaging to study the interactions between transplanted stem cells, blood vessels, and nerves during bone healing. Feel free to stop by tomorrow (4/28) at 1 pm!
December 10, 2024 at 11:48 PM
If you're at @SFBiomaterials #SFB2022, I'll be presenting our @GraysonLab research using #tissueclearing & #lightsheet imaging to study the interactions between transplanted stem cells, blood vessels, and nerves during bone healing. Feel free to stop by tomorrow (4/28) at 1 pm!
Defended my PhD thesis today! It still feels a bit surreal, but I am very happy to be #PhDone!
December 10, 2024 at 11:48 PM
Defended my PhD thesis today! It still feels a bit surreal, but I am very happy to be #PhDone!
Starting 2022 with a dusting of AZ snow. I wish everyone a happy and healthy New Year! 🎉🎉
December 10, 2024 at 11:48 PM
Starting 2022 with a dusting of AZ snow. I wish everyone a happy and healthy New Year! 🎉🎉
Gave this a try on my thesis. Maybe I can use it for Halloween decorations next year. 😂
"Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution"
https://app.wombo.art/
"Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution"
https://app.wombo.art/
December 10, 2024 at 11:48 PM
Gave this a try on my thesis. Maybe I can use it for Halloween decorations next year. 😂
"Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution"
https://app.wombo.art/
"Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution"
https://app.wombo.art/
Thanks to my boyfriend Kyle for a wonderful birthday dinner at Water for Chocolate! I'm trying to take advantage of those peak Moderna booster antibodies while they last 😂 I definitely recommend WFC for those living in Baltimore if you haven't been yet!
December 10, 2024 at 11:48 PM
Thanks to my boyfriend Kyle for a wonderful birthday dinner at Water for Chocolate! I'm trying to take advantage of those peak Moderna booster antibodies while they last 😂 I definitely recommend WFC for those living in Baltimore if you haven't been yet!
Special thanks to @srsnyder_biomed for creating this wonderful illustration to summarize our findings! (13/16)
December 10, 2024 at 11:49 PM
Special thanks to @srsnyder_biomed for creating this wonderful illustration to summarize our findings! (13/16)
Using a cranial defect injury model, we found that CD31(hi)Emcn(hi) vessels—along with Gli1+ progenitors—infiltrate the entire defect area during the early stages of healing. This result implicates a potential role for these vessels in driving cranial bone healing. (9/16)
December 10, 2024 at 11:49 PM
Using a cranial defect injury model, we found that CD31(hi)Emcn(hi) vessels—along with Gli1+ progenitors—infiltrate the entire defect area during the early stages of healing. This result implicates a potential role for these vessels in driving cranial bone healing. (9/16)
However, conditionally knocking out PDGF-BB in TRAP+ osteo/pre-osteoclasts disrupted this relationship, which suggests that these bone-resorbing cells may be critical in maintaining the native cranial microvascular environment. (8/16)
December 10, 2024 at 11:49 PM
However, conditionally knocking out PDGF-BB in TRAP+ osteo/pre-osteoclasts disrupted this relationship, which suggests that these bone-resorbing cells may be critical in maintaining the native cranial microvascular environment. (8/16)
We discovered that CD31(hi)Emcn(hi) vessels were spatially correlated with Osterix+ and Gli1+ progenitors during growth and healing. This relationship was most prominent at the transcortical canals (white arrowheads), where periosteal vessels connect to marrow sinusoids. (7/16)
December 10, 2024 at 11:49 PM
We discovered that CD31(hi)Emcn(hi) vessels were spatially correlated with Osterix+ and Gli1+ progenitors during growth and healing. This relationship was most prominent at the transcortical canals (white arrowheads), where periosteal vessels connect to marrow sinusoids. (7/16)
Very excited to share our paper from the @GraysonLab on imaging the cranial microvascular environment using #tissueclearing and #lightsheet microscopy. See 🧵 below for the story behind our study and the link to our publicly available datasets! (1/16)
https://www.nature.com/articles/s41467-021-26...
https://www.nature.com/articles/s41467-021-26...
December 10, 2024 at 11:49 PM
Very excited to share our paper from the @GraysonLab on imaging the cranial microvascular environment using #tissueclearing and #lightsheet microscopy. See 🧵 below for the story behind our study and the link to our publicly available datasets! (1/16)
https://www.nature.com/articles/s41467-021-26...
https://www.nature.com/articles/s41467-021-26...
Arizona sunsets never get old :)
December 10, 2024 at 11:48 PM
Arizona sunsets never get old :)
Incredibly proud of my boyfriend, Kyle Keraga, who just graduated first in his law class at @UMDLaw!
December 10, 2024 at 11:48 PM
Incredibly proud of my boyfriend, Kyle Keraga, who just graduated first in his law class at @UMDLaw!
Ongoing #BroodX invasion happening at the @JohnsHopkins Homewood Campus! 😮
December 10, 2024 at 11:48 PM
Ongoing #BroodX invasion happening at the @JohnsHopkins Homewood Campus! 😮
Got my hair cut for the first time in over a year. Thank you vaccines! (and science!)
December 10, 2024 at 11:48 PM
Got my hair cut for the first time in over a year. Thank you vaccines! (and science!)
Starting off 2021 by making @nytfood's eggnog snickerdoodles with Kyle! 😋🍪 Happy New Year everybody!
December 10, 2024 at 11:48 PM
Starting off 2021 by making @nytfood's eggnog snickerdoodles with Kyle! 😋🍪 Happy New Year everybody!
Kyle gave me this extraordinarily soft and cozy blanket from @bigblanketco for Christmas this year, but I guess it belongs to Chai now! 🐱😂 Merry Christmas everyone!
December 10, 2024 at 11:48 PM
Kyle gave me this extraordinarily soft and cozy blanket from @bigblanketco for Christmas this year, but I guess it belongs to Chai now! 🐱😂 Merry Christmas everyone!
We are delighted to share our new preprint from the @GraysonLab! In this article, we develop a novel quantitative imaging platform to study the cranial microvascular environment at single-cell resolution. More details in thread below:
https://www.biorxiv.org/content/10.1101/2020.12.08.417014v1
https://www.biorxiv.org/content/10.1101/2020.12.08.417014v1
December 10, 2024 at 11:48 PM
We are delighted to share our new preprint from the @GraysonLab! In this article, we develop a novel quantitative imaging platform to study the cranial microvascular environment at single-cell resolution. More details in thread below:
https://www.biorxiv.org/content/10.1101/2020.12.08.417014v1
https://www.biorxiv.org/content/10.1101/2020.12.08.417014v1
Ballot accepted 😃 Ready to send another astronaut, @CaptMarkKelly, to the US Senate! 🚀🗳️🇺🇸 #ELECTION2020 #GoVote
December 10, 2024 at 11:48 PM
Ballot accepted 😃 Ready to send another astronaut, @CaptMarkKelly, to the US Senate! 🚀🗳️🇺🇸 #ELECTION2020 #GoVote
Just mailed in my ballot! Thank you to @jhscipolgroup for the awesome #STEMulateTheVote swag! :) I encourage everyone to make plans to vote if you haven't already. Our voices as scientists and engineers are especially important in this election! 🧪🔬☑️🗳️
December 10, 2024 at 11:48 PM
Just mailed in my ballot! Thank you to @jhscipolgroup for the awesome #STEMulateTheVote swag! :) I encourage everyone to make plans to vote if you haven't already. Our voices as scientists and engineers are especially important in this election! 🧪🔬☑️🗳️
Hi @BMESDiversity and @EveryDayBME! I am a @JHUBME PhD student working in the @GraysonLab to develop therapies to regenerate bone following injury. I love BME since I can apply math and science toward improving patients' quality of life! #DiversityinBMEWeek
December 10, 2024 at 11:49 PM
Hi @BMESDiversity and @EveryDayBME! I am a @JHUBME PhD student working in the @GraysonLab to develop therapies to regenerate bone following injury. I love BME since I can apply math and science toward improving patients' quality of life! #DiversityinBMEWeek
Got my flu shot at @HopkinsMedicine today! I encourage everyone to get theirs as soon as they can!
December 10, 2024 at 11:49 PM
Got my flu shot at @HopkinsMedicine today! I encourage everyone to get theirs as soon as they can!