Mark Levin
@levinchem.bsky.social
Professor of Chemistry
University of Chicago
Single-Atom Skeletal Editing
(Interspersed with doomposting and AI skepticism)
Husband, Dad, Crossword Addict
http://levingroup.uchicago.edu
University of Chicago
Single-Atom Skeletal Editing
(Interspersed with doomposting and AI skepticism)
Husband, Dad, Crossword Addict
http://levingroup.uchicago.edu
Today in @science.org, @mikusp.bsky.social reports a method to replace the C2 of pyridines with N, affording pyridazines.
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
July 17, 2025 at 11:13 PM
Today in @science.org, @mikusp.bsky.social reports a method to replace the C2 of pyridines with N, affording pyridazines.
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...
The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.
www.science.org/doi/10.1126/...