Leo Steg
@leocsteg.bsky.social
Chromatin research and science gossip.
PhD student at ETH and University Zurich.
PhD student at ETH and University Zurich.
Our review on paternal intergenerational epigenetic inheritance and the instructive sperm epigenome is now out!
We summarize how the paternal genome instructs the earliest stages of embryonic development and how environmental exposures can reshape this process.
doi.org/10.1080/1750...
We summarize how the paternal genome instructs the earliest stages of embryonic development and how environmental exposures can reshape this process.
doi.org/10.1080/1750...
A father’s legacy: the sperm epigenome, preimplantation development, and paternal environment
Paternal exposure to the environment can influence offspring phenotypes via a process known as intergenerational epigenetic inheritance. Such form of inheritance involves the sperm epigenome that i...
doi.org
October 8, 2025 at 5:11 PM
Our review on paternal intergenerational epigenetic inheritance and the instructive sperm epigenome is now out!
We summarize how the paternal genome instructs the earliest stages of embryonic development and how environmental exposures can reshape this process.
doi.org/10.1080/1750...
We summarize how the paternal genome instructs the earliest stages of embryonic development and how environmental exposures can reshape this process.
doi.org/10.1080/1750...
Reposted by Leo Steg
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Reposted by Leo Steg
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
April 14, 2025 at 8:08 PM
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Reposted by Leo Steg
The DNA in our cells is not naked but instead is compacted by being wrapped around nucleosomes assembled from histone proteins. In our current view, this produces the chromatin architecture that leaves some regions open for transcription while others are more compacted & transcriptionally silent 1/n
March 28, 2025 at 11:03 AM
The DNA in our cells is not naked but instead is compacted by being wrapped around nucleosomes assembled from histone proteins. In our current view, this produces the chromatin architecture that leaves some regions open for transcription while others are more compacted & transcriptionally silent 1/n
Reposted by Leo Steg
We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @naturecomms.bsky.social today: www.nature.com/articles/s41...
CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks - Nature Communications
Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required. This study shows that CUT&T...
www.nature.com
March 27, 2025 at 11:16 AM
We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @naturecomms.bsky.social today: www.nature.com/articles/s41...
Reposted by Leo Steg
This is a reminder that there is still space in this starter pack if you want to join 🤩. Just send us a message!
Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN
December 5, 2024 at 8:42 AM
This is a reminder that there is still space in this starter pack if you want to join 🤩. Just send us a message!
Reposted by Leo Steg
Postdoc positions in epigenetics!
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS
December 2, 2024 at 11:32 AM
Postdoc positions in epigenetics!
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS