Ernst Lengyel
@lengyel-ovca-lab.bsky.social
Physician scientist studying ovarian cancer
https://obgyn.uchicago.edu/research/lengyelkenny-ovarian-cancer-laboratory
https://obgyn.uchicago.edu/research/lengyelkenny-ovarian-cancer-laboratory
Pinned
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Epithelial serous borderline tumors (SBT) are non-invasive neoplastic ovarian lesions that may recur as chemo-resistant low-grade serous cancer (LGSC)…
www.sciencedirect.com
Proud to share our latest work in #CancerCell in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
I’m proud to share our lab's latest work in collaboration with
@mannlab.bsky.social is featured on the cover of @cp-cancercell.bsky.social. The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs.
Read the publication: www.cell.com/cancer-cell/...
@mannlab.bsky.social is featured on the cover of @cp-cancercell.bsky.social. The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs.
Read the publication: www.cell.com/cancer-cell/...
August 12, 2025 at 8:52 PM
I’m proud to share our lab's latest work in collaboration with
@mannlab.bsky.social is featured on the cover of @cp-cancercell.bsky.social. The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs.
Read the publication: www.cell.com/cancer-cell/...
@mannlab.bsky.social is featured on the cover of @cp-cancercell.bsky.social. The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs.
Read the publication: www.cell.com/cancer-cell/...
Reposted by Ernst Lengyel
Leap onto the August issue of Cancer Cell, out now: www.cell.com/cancer-cell/...
August 11, 2025 at 3:47 PM
Leap onto the August issue of Cancer Cell, out now: www.cell.com/cancer-cell/...
Proud to share our new @nature.com study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy.
nature.com/articles/s41...
nature.com/articles/s41...
July 23, 2025 at 8:29 PM
Proud to share our new @nature.com study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy.
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Ernst Lengyel
New in @nature.com: Drs. @lengyel-ovca-lab.bsky.social, Janna Heide & co-authors discovered a first-of-its-kind NNMT inhibitor that reprograms cancer-associated fibroblasts and restores immune response in ovarian cancer. A major step toward more effective therapies.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...
www.nature.com
July 23, 2025 at 8:00 PM
New in @nature.com: Drs. @lengyel-ovca-lab.bsky.social, Janna Heide & co-authors discovered a first-of-its-kind NNMT inhibitor that reprograms cancer-associated fibroblasts and restores immune response in ovarian cancer. A major step toward more effective therapies.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ernst Lengyel
🔥 Hot off the press: In a new @nature.com study, Ernst Lengyel, MD, PhD and team show that blocking NNMT in tumor-supporting cells restores immune response & stops ovarian cancer growth, offering a new strategy to treat one of the deadliest cancers. @lengyel-ovca-lab.bsky.social
ow.ly/zzfZ50Wu3UW
ow.ly/zzfZ50Wu3UW
July 23, 2025 at 3:26 PM
🔥 Hot off the press: In a new @nature.com study, Ernst Lengyel, MD, PhD and team show that blocking NNMT in tumor-supporting cells restores immune response & stops ovarian cancer growth, offering a new strategy to treat one of the deadliest cancers. @lengyel-ovca-lab.bsky.social
ow.ly/zzfZ50Wu3UW
ow.ly/zzfZ50Wu3UW
Reposted by Ernst Lengyel
I’m thrilled to share that the main work of my PhD has been published @cp-cancercell.bsky.social ! With @mannlab.bsky.social & @lengyel-ovca-lab.bsky.social, we mapped the progression from borderline ovarian tumors to LGSC using spatial proteo-transcriptomics and identified new therapeutic targets.
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Schweizer et al. profile the tumor progression from non-invasive serous borderline
tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating
cell-type resolved Deep Visual Prot...
www.cell.com
June 27, 2025 at 5:30 AM
I’m thrilled to share that the main work of my PhD has been published @cp-cancercell.bsky.social ! With @mannlab.bsky.social & @lengyel-ovca-lab.bsky.social, we mapped the progression from borderline ovarian tumors to LGSC using spatial proteo-transcriptomics and identified new therapeutic targets.
Reposted by Ernst Lengyel
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Proteomics and spatial transcriptomics, they identify and validate several drivers of transformation as well as a novel combination treatment for this chemo-resistant disease.
dlvr.it
June 27, 2025 at 2:17 PM
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Reposted by Ernst Lengyel
An interdisciplinary study uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy.
❕Publication: www.cell.com/cancer-cell/...
❕Press Release: www.biochem.mpg.de/when-tumors-...
❕Publication: www.cell.com/cancer-cell/...
❕Press Release: www.biochem.mpg.de/when-tumors-...
June 26, 2025 at 5:27 PM
An interdisciplinary study uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy.
❕Publication: www.cell.com/cancer-cell/...
❕Press Release: www.biochem.mpg.de/when-tumors-...
❕Publication: www.cell.com/cancer-cell/...
❕Press Release: www.biochem.mpg.de/when-tumors-...
Reposted by Ernst Lengyel
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Schweizer et al. profile the tumor progression from non-invasive serous borderline
tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating
cell-type resolved Deep Visual Prot...
www.cell.com
June 26, 2025 at 3:20 PM
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Proud to share our latest work in #CancerCell in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Epithelial serous borderline tumors (SBT) are non-invasive neoplastic ovarian lesions that may recur as chemo-resistant low-grade serous cancer (LGSC)…
www.sciencedirect.com
June 26, 2025 at 4:35 PM
Proud to share our latest work in #CancerCell in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
We describe a comprehensive cell atlas of healthy human fallopian tubes during the menstrual cycle and menopause using single-cell RNA and ATAC sequencing in NatureCommunication. Team work with Drs. Weigert, Li, Chen, Basu
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause - Nature Communications
The fallopian tube undergoes extensive cellular and molecular changes during the menstrual cycle and aging. Here, Weigert et al. present a single-cell atlas of the normal human fallopian tube revealin...
www.nature.com
February 8, 2025 at 5:41 AM
We describe a comprehensive cell atlas of healthy human fallopian tubes during the menstrual cycle and menopause using single-cell RNA and ATAC sequencing in NatureCommunication. Team work with Drs. Weigert, Li, Chen, Basu
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We participated in a study led by Honami Naora Ph.D. from MD Anderson characterizing the role of B-cells in early ovarian cancer metastasis
“Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10”
dlvr.it/TH7nCc
“Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10”
dlvr.it/TH7nCc
January 9, 2025 at 2:42 AM
We participated in a study led by Honami Naora Ph.D. from MD Anderson characterizing the role of B-cells in early ovarian cancer metastasis
“Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10”
dlvr.it/TH7nCc
“Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10”
dlvr.it/TH7nCc