Lee Sherry
@leesherry.bsky.social
Post-doc developing ex vivo immune organoids for improved translation of novel vaccine candidates at the MRC-University of Glasgow Centre for Virus Research
4/7 Despite this similarity, this new PV2 VLP displayed increased increased immunogenicity compared to its predecessor, and in the presence of adjuvant was as immunogenic as the current IPV vaccine
April 7, 2025 at 4:44 PM
4/7 Despite this similarity, this new PV2 VLP displayed increased increased immunogenicity compared to its predecessor, and in the presence of adjuvant was as immunogenic as the current IPV vaccine
3/7 We also produced a different PV2 mutant, which significantly increased VLP yields and improved particle thermostability. The team @ox.ac.uk (STRUBI) then determined the structure of these mutants by cryoEM and found them to be highly similar
April 7, 2025 at 4:44 PM
3/7 We also produced a different PV2 mutant, which significantly increased VLP yields and improved particle thermostability. The team @ox.ac.uk (STRUBI) then determined the structure of these mutants by cryoEM and found them to be highly similar
2/7 This paper follows on from our previous work, highlighting how immunogenic poliovirus virus-like particles (PV VLPs) made in yeast can be made at scale using fermentation with increased yields compared to flask-based expression
April 7, 2025 at 4:44 PM
2/7 This paper follows on from our previous work, highlighting how immunogenic poliovirus virus-like particles (PV VLPs) made in yeast can be made at scale using fermentation with increased yields compared to flask-based expression
Great few days in Liverpool for @microbiologysociety.org conference, can't wait to catch up with everyone again next year! #Microbio25
April 3, 2025 at 11:23 AM
Great few days in Liverpool for @microbiologysociety.org conference, can't wait to catch up with everyone again next year! #Microbio25
6/ So we took inspiration from other VLP vaccines and used an adjuvant, which worked beautifully! With VLPs for all three poliovirus serotypes being more or as immunogenic as IPV in the rat model!
January 27, 2025 at 8:24 PM
6/ So we took inspiration from other VLP vaccines and used an adjuvant, which worked beautifully! With VLPs for all three poliovirus serotypes being more or as immunogenic as IPV in the rat model!
4/ We then needed to determine if these VLPs were immunogenic. The team at NIBSC-MHRA Vaccine Division assessed how well these VLPs induced neutralising antibodies in comparison to the current vaccine (IPV), using a mouse model, highlighting that all the VLPs tested were as immunogenic as IPV
January 27, 2025 at 8:24 PM
4/ We then needed to determine if these VLPs were immunogenic. The team at NIBSC-MHRA Vaccine Division assessed how well these VLPs induced neutralising antibodies in comparison to the current vaccine (IPV), using a mouse model, highlighting that all the VLPs tested were as immunogenic as IPV
3/ The team @ox.ac.uk (STRUBI) then analysed the VLPs produced from each expression system by cryo-EM to ensure that these particles have the correct conformation and maintain the known immune epitopes present on infectious virions
January 27, 2025 at 8:24 PM
3/ The team @ox.ac.uk (STRUBI) then analysed the VLPs produced from each expression system by cryo-EM to ensure that these particles have the correct conformation and maintain the known immune epitopes present on infectious virions
2/ Naturally occurring empty capsids undergo a conformational change meaning that they no longer produce a long-lasting immune response. Therefore, our consortium have identified a number of mutations which maintains the D Ag conformation which induces long-lasting immunity
January 27, 2025 at 8:24 PM
2/ Naturally occurring empty capsids undergo a conformational change meaning that they no longer produce a long-lasting immune response. Therefore, our consortium have identified a number of mutations which maintains the D Ag conformation which induces long-lasting immunity