@ldaubrey.bsky.social
Post-Doc currently in Sheena Radford's lab (Leeds). Previously worked for Wei-Feng Xue (Kent). Interested in amyloid fibril structures. Except for the bits that can be resolved to high resolution resolution by cryo-EM. Terrible golfer.
Reposted
But then we had a surprise – cana and a related inhibitor also profoundly change the final structure of amyloid fibrils.
This suggests that early events in amyloid formation are crucial for determining the subsequent structures of fibril polymorphs.
(4/6)
This suggests that early events in amyloid formation are crucial for determining the subsequent structures of fibril polymorphs.
(4/6)
April 10, 2025 at 3:17 PM
But then we had a surprise – cana and a related inhibitor also profoundly change the final structure of amyloid fibrils.
This suggests that early events in amyloid formation are crucial for determining the subsequent structures of fibril polymorphs.
(4/6)
This suggests that early events in amyloid formation are crucial for determining the subsequent structures of fibril polymorphs.
(4/6)
I realised it would be easier to show (than tell) some of this so I made CoFiSim, which simulates the fibril assembly (by numerically integrating rate equations) of 2 structures with independent rate constants competing for the same pool of monomer colab.research.google.com/drive/1DTCco...
February 28, 2025 at 11:41 AM
I realised it would be easier to show (than tell) some of this so I made CoFiSim, which simulates the fibril assembly (by numerically integrating rate equations) of 2 structures with independent rate constants competing for the same pool of monomer colab.research.google.com/drive/1DTCco...