Luisa Cochella
@lcochella.bsky.social
Proud worm researcher. Interested in miRNAs, all RNAs really, and gene regulation in general. A biochemist turned geneticist trying to think about questions of cell biology. Lucky to lead a lab at Johns Hopkins School of medicine. https://cochellalab.org/
In a tour de force experiment, Emilio made a worm strain with 13 variant 3'UTRs, mutating the miR-51/miR-100 binding sites in high confidence targets. This phenocopies some of the defects observed upon loss of the miRNA, providing causality between modest derepression of many targets and phenotype!
September 3, 2025 at 6:16 PM
In a tour de force experiment, Emilio made a worm strain with 13 variant 3'UTRs, mutating the miR-51/miR-100 binding sites in high confidence targets. This phenocopies some of the defects observed upon loss of the miRNA, providing causality between modest derepression of many targets and phenotype!