Jana Seifert, Julia Oh, Yongqi Shao, Markus Hilty, Purnima Kumar, Falk Hildebrand, Connie Lovejoy, Paul Wigley, Ke Yu, Meiling Zhang, Tong Zhang, Jens Walter, Mahesh Desai, Sharon Huws, Lynn M. Schriml, Jacques Ravel, W. Florian Fricke, Emiley Eloe-Fadrosh, Charles Lee, Thomas Clavel

We think that such efforts are essential to push the boundaries of our knowledge on microbiomes in a concerted, international effort.

If your manuscript fit these expectations, please submit it to Microbiome ! @microbiomej.bsky.social

With Joy Watts, Kevin Theis, Víctor Carrion, Adam Ossowicki,

Manuscripts need to meet high standards of language accuracy, quality of microbiome analyses, and data and protocol availability, including detailed reporting of wet-lab and in silico protocols, all of which can critically enhance transparency and reproducibility.

We take the opportunity to clarify our expectations for the articles submitted to the journal. At Microbiome, we are seeking studies that provide either new mechanistic insights into the role of microbiomes in health and environmental systems or substantial conceptual or technical advances.

More broadly, our work demonstrates the interest and relevance of microbial activity measurements using stable isotopes, an approach currently underused in the microbiome field.

Altogether, this work highlights the contribution of the gut microbiota to bile acid dysmetabolism and the therapeutic interest of the secondary bile acid TDCA for hepatic cholesterol homeostasis in the context of cancer cachexia.

(iii) administration of one of these bile acids, the taurodeoxycholic acid (TDCA), counteracted muscle atrophy (in vitro) 💪 and improved cholesterol homeostasis (in vivo).

In this manuscript, we established that (i) secondary bile acids are reduced in 3 mouse models of cancer cachexia, (ii) these alterations ensue from an altered bacterial metabolism of bile acids 🦠and

Indeed, thanks for the invitation! A new world for me 🌍

Looking forward to it!

Congrats Aneesha for your position!