Laura Fedele
@lau-fed.bsky.social
👩🔬Neuroscientist interested in cellular excitability/in vitro models-often found patching sensory or autonomic neurons. Postdoc at WolfsonSPaRC, King's College London | iPSC-neurons | patch clamp | ion channels| neuro-cardiac interactions
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes
Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, ...
doi.org
October 27, 2025 at 4:54 PM
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
Reposted by Laura Fedele
#CPW2025 is now over, but we're already planning for #CPW2026 🦑🧠🫀🔬
To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here:
forms.office.com/e/PTh5qMvmUM
Please share the link with your electrophysiology trainees. 🙂
To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here:
forms.office.com/e/PTh5qMvmUM
Please share the link with your electrophysiology trainees. 🙂
August 27, 2025 at 8:32 AM
#CPW2025 is now over, but we're already planning for #CPW2026 🦑🧠🫀🔬
To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here:
forms.office.com/e/PTh5qMvmUM
Please share the link with your electrophysiology trainees. 🙂
To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here:
forms.office.com/e/PTh5qMvmUM
Please share the link with your electrophysiology trainees. 🙂
Reposted by Laura Fedele
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further!
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...
www.biorxiv.org
August 20, 2025 at 12:22 PM
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further!
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
Reposted by Laura Fedele
Cannot believe that week one of the @cpw-liverpool.bsky.social is nearly over! A brilliant week so far! Thank you to everyone who has contributed so far, especially to the @biologists.bsky.social for their funding of our 40th workshop!
August 15, 2025 at 10:36 AM
Cannot believe that week one of the @cpw-liverpool.bsky.social is nearly over! A brilliant week so far! Thank you to everyone who has contributed so far, especially to the @biologists.bsky.social for their funding of our 40th workshop!
Reposted by Laura Fedele
The @cpw-liverpool.bsky.social has completed the first week; another brilliant first week with an outstanding cohort of participants!
Looking forward to week 2…after a few nights sleep!
Looking forward to week 2…after a few nights sleep!
August 15, 2025 at 6:21 PM
The @cpw-liverpool.bsky.social has completed the first week; another brilliant first week with an outstanding cohort of participants!
Looking forward to week 2…after a few nights sleep!
Looking forward to week 2…after a few nights sleep!
Reposted by Laura Fedele
Some scenes from this year's Work Experience event, where we hosted a group of A-Level students for a week and gave them a variety of demonstrations, hands-on experiments, and lectures.
August 6, 2025 at 1:56 PM
Some scenes from this year's Work Experience event, where we hosted a group of A-Level students for a week and gave them a variety of demonstrations, hands-on experiments, and lectures.
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
July 29, 2025 at 5:15 PM
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
Honoured to have presented at the super cool Ephys Club⚡😎👩🔬 and thank you for all the constructive comments!
Another successful Ephys Club! Pizza 🍕, refreshments 🥤 and an amazing talk from Laura Fedele, who set up a rig all by herself and managed to get successful recordings from iPSCs all in less than a year!
Thanks to our sponsor Scientifica for making it possible!
Thanks to our sponsor Scientifica for making it possible!
June 27, 2025 at 8:06 AM
Honoured to have presented at the super cool Ephys Club⚡😎👩🔬 and thank you for all the constructive comments!
Reposted by Laura Fedele
Many thanks to @theorah.bsky.social who did a wonderful job as our comic artist and bringing Professor SPaRC to life!
Introducing Professor SPaRC! To contribute to Science Week, members of our department will be visiting local schools to teach children about the brain and the human nervous system with models, interactive classes and comics! @kingsioppn.bsky.social #BSW25
March 18, 2025 at 4:44 PM
Many thanks to @theorah.bsky.social who did a wonderful job as our comic artist and bringing Professor SPaRC to life!
Super happy to share our work just published in @jphysiol.bsky.social
led by Neda Mohammadi and a amaxing work by all the authors!
We show that sympathetic neurons can enhance the maturity of stem cell derived cardiomyocytes structurally and functionally- exciting data for neurocardiac models!
led by Neda Mohammadi and a amaxing work by all the authors!
We show that sympathetic neurons can enhance the maturity of stem cell derived cardiomyocytes structurally and functionally- exciting data for neurocardiac models!
February 27, 2025 at 5:43 PM
Super happy to share our work just published in @jphysiol.bsky.social
led by Neda Mohammadi and a amaxing work by all the authors!
We show that sympathetic neurons can enhance the maturity of stem cell derived cardiomyocytes structurally and functionally- exciting data for neurocardiac models!
led by Neda Mohammadi and a amaxing work by all the authors!
We show that sympathetic neurons can enhance the maturity of stem cell derived cardiomyocytes structurally and functionally- exciting data for neurocardiac models!
Reposted by Laura Fedele
Congrats to the team for their ongoing commitment to the IoPPN Research Culture Fund in their successful running of the CommuniTEA event on Guy's Campus! @lau-fed.bsky.social @juliavw.bsky.social ☕️ #CommuniTEA
Learn more here: www.kcl.ac.uk/news/seven-p...
Learn more here: www.kcl.ac.uk/news/seven-p...
February 19, 2025 at 4:41 PM
Congrats to the team for their ongoing commitment to the IoPPN Research Culture Fund in their successful running of the CommuniTEA event on Guy's Campus! @lau-fed.bsky.social @juliavw.bsky.social ☕️ #CommuniTEA
Learn more here: www.kcl.ac.uk/news/seven-p...
Learn more here: www.kcl.ac.uk/news/seven-p...
These research models trump cards look so much fun!! Amazing work @comeflywithjo.bsky.social !!!
#StemCells #STEMoutreach #neuroskyence
#StemCells #STEMoutreach #neuroskyence
Check out the Trump cards designed by @comeflywithjo.bsky.social, featuring all kinds of research models, from fruit flies to sea urchins to organoids🪰🐸🐟
Get in touch with Jo if you'd like to use the cards as part of your teaching/ outreach activities!
#DevBio #StemCells #STEMoutreach
Get in touch with Jo if you'd like to use the cards as part of your teaching/ outreach activities!
#DevBio #StemCells #STEMoutreach
Top Trumps - but make it science 🤓 I had the most fun designing these, and I've written about how you could use it in your outreach programme!
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
January 7, 2025 at 10:20 AM
These research models trump cards look so much fun!! Amazing work @comeflywithjo.bsky.social !!!
#StemCells #STEMoutreach #neuroskyence
#StemCells #STEMoutreach #neuroskyence