Lars Velten
@larsplus.bsky.social
Group leader @crg.eu | blood, single cell, synthetic genomics
🇬🇧: Finally, English-language coverage by Financial Times, a small London-based newspaper 😉. Thanks again @omarjam.bsky.social and Nahia (@irbbarcelona.org) for making all this possible! www.ft.com/content/a1f8...
Scientists make breakthroughs on blood ageing and limb regrowth
Two new studies could help develop better therapies for rejuvenation and regeneration
www.ft.com
May 31, 2025 at 12:44 PM
🇬🇧: Finally, English-language coverage by Financial Times, a small London-based newspaper 😉. Thanks again @omarjam.bsky.social and Nahia (@irbbarcelona.org) for making all this possible! www.ft.com/content/a1f8...
😵💫: Private TV antenna3 hectically shot an interview 1.5h before their 3pm news, got a lot wrong (no we did not rejuvenate mice by ablating old stem cells, Irv Weissman did that) BUT they made us the good news of the day and it's somehow funny www.antena3.com/noticias/cie...
Científicos españoles descubren cómo envejece la sangre: un gran hallazgo para la lucha contra la leucemia y el envejecimiento
Un estudio desarrollado en Barcelona ha dado con la clave para entender cómo envejece la sangre. El hallazgo podría facilitar la detección temprana de enfermedades como la leucemia y abrir nuevas vías...
www.antena3.com
May 31, 2025 at 12:44 PM
😵💫: Private TV antenna3 hectically shot an interview 1.5h before their 3pm news, got a lot wrong (no we did not rejuvenate mice by ablating old stem cells, Irv Weissman did that) BUT they made us the good news of the day and it's somehow funny www.antena3.com/noticias/cie...
😬: SER Catalunya, most-listened radio around here, interviewed me at 8:40 (instead of 8:50)... they reached me in the elevator, put me live on air and started asking in Catalan. Had to guess what they meant and improvise. The good thing, I was awake after this 😅 (can't upload audio to bsky - 7/n)
May 31, 2025 at 12:44 PM
😬: SER Catalunya, most-listened radio around here, interviewed me at 8:40 (instead of 8:50)... they reached me in the elevator, put me live on air and started asking in Catalan. Had to guess what they meant and improvise. The good thing, I was awake after this 😅 (can't upload audio to bsky - 7/n)
🇫🇷: @scherermich.bsky.social was brave enough to speak to @lemonde.fr in French 💪! Excellent article that definitely sticks out with the accompanying visual.
www.lemonde.fr/sciences/art... (6/n)
www.lemonde.fr/sciences/art... (6/n)
Dès l’âge de 50 ans, les cellules de notre sang s’appauvrissent
Une équipe espagnole a retracé l’évolution des lignées de cellules du sang chez 13 personnes de 35 à 70 ans. A partir de la cinquantaine, le nombre de cellules souches capables d’engendrer des cellule...
www.lemonde.fr
May 31, 2025 at 12:44 PM
🇫🇷: @scherermich.bsky.social was brave enough to speak to @lemonde.fr in French 💪! Excellent article that definitely sticks out with the accompanying visual.
www.lemonde.fr/sciences/art... (6/n)
www.lemonde.fr/sciences/art... (6/n)
🇦🇹: Austrian ORF covered both the blood ageing context and the DNA methylation discovery in two minutes on the radio after interviewing @martinabraun.bsky.social and me. Real quality science journalism. science.orf.at/stories/3230... (5/n)
„Blutbarcodes“ könnten Alterung verlangsamen
Auch das Blut altert: Ab 50 Jahren verringert sich die Vielfalt der Stammzellen, die Blut produzieren. Ein Forschungsteam hat nun ein „Barcodesystem“ entwickelt, das die verschiedenen Blutstammzellen ...
science.orf.at
May 31, 2025 at 12:44 PM
🇦🇹: Austrian ORF covered both the blood ageing context and the DNA methylation discovery in two minutes on the radio after interviewing @martinabraun.bsky.social and me. Real quality science journalism. science.orf.at/stories/3230... (5/n)
😅: "From age 50 almost all stem cells are called Rodriguez (and that's bad)". All credit for this to @alejofraticelli.bsky.social - family names are a fantastic analogy to explain clonal processes cadenaser.com/nacional/202... (4/n)
"A partir de los 50 casi todas las células madre se llaman Rodríguez" (Y eso es malo)
Un estudio liderado por dos centros de investigación de Barcelona ha descubierto que, a partir de esa edad, cada vez tenemos menos células madre sanguíneas y las que hay se replican cada vez con más e...
cadenaser.com
May 31, 2025 at 12:44 PM
😅: "From age 50 almost all stem cells are called Rodriguez (and that's bad)". All credit for this to @alejofraticelli.bsky.social - family names are a fantastic analogy to explain clonal processes cadenaser.com/nacional/202... (4/n)
❤️: Catalan public TV 3cat nicely covered the science and the emotions when making a cool discovery in their evening news (almost like Sports reporting) www.3cat.cat/3cat/envelli... (3/n)
Telenotícies - Envelliment de la sang: d'un ecosistema ric i variat a un de dominat per unes poques cèl·lules - 3Cat
Una investigació catalana rastreja els "codis de barres" escrits a l'ADN i revela què passa a la sang quan envellim.
www.3cat.cat
May 31, 2025 at 12:44 PM
❤️: Catalan public TV 3cat nicely covered the science and the emotions when making a cool discovery in their evening news (almost like Sports reporting) www.3cat.cat/3cat/envelli... (3/n)
First of all, here's the science, in case you missed it. bsky.app/profile/lars...
Now come the media highlights (2/n)
Now come the media highlights (2/n)
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 31, 2025 at 12:44 PM
First of all, here's the science, in case you missed it. bsky.app/profile/lars...
Now come the media highlights (2/n)
Now come the media highlights (2/n)
What a year 😅 really really happy that both these projects worked out better that we could ever have planned, and the Barcelona scientific environment was super important for both of them!
May 21, 2025 at 9:15 PM
What a year 😅 really really happy that both these projects worked out better that we could ever have planned, and the Barcelona scientific environment was super important for both of them!
It was great to see how this story rapidly developed from a serendipitous discovery on DNA methylation to a project with relevance to blood stem cell ageing and beyond. Big thanks to the funders, especially EHA and AECC.
May 21, 2025 at 3:44 PM
It was great to see how this story rapidly developed from a serendipitous discovery on DNA methylation to a project with relevance to blood stem cell ageing and beyond. Big thanks to the funders, especially EHA and AECC.
With help of @leifludwig.bsky.social @caleblareau.bsky.social & colleagues, we compared this to mitochondrial lineage tracing; TL;DR: mitochondrial genetics is complicated (12/n)
May 21, 2025 at 3:44 PM
With help of @leifludwig.bsky.social @caleblareau.bsky.social & colleagues, we compared this to mitochondrial lineage tracing; TL;DR: mitochondrial genetics is complicated (12/n)