Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC

events.faseb.org/event/Mechan...

What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1...
1/n

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!

Celebrating 140 Years of Women in Engineering at Cornell @cornellengineering.bsky.social and their amazing achievements.
Hosted by @mchvdm.bsky.social and Lara Estroff, trailblazers in their own right.

For #FluorescenceFriday, a found an old video of MDA-MB-231 cells in a dense collagen matrix dividing, acquired on a lattice lightsheet microscope at the @aicjanelia.bsky.social. Mitotic chromosomes are fun to watch! This was just a quick test video, hence the limited but still impressive quality.

Meet the amazing people behind our research, a fantastic team of scientists and engineers from various disciplines and countries, united in their interest in #mechanobiology and its application to basic science and disease. Plus a huge passion for working together and enriching the community.

A late entry for #FluorescenceFriday or an early post for #MicroscopyMonday, reposting a movie of a breast cancer cell migrating through a small microfluidic constriction by contracting its rear cortex. You can find the full story at journals.biologists.com/jcs/article-...

Sharing this on behalf of the Connecting Intermediate Filaments community: Tune in next Wednesday November 20, for our first #ConnectingIFs seminar of the season 2024-2025, with Prof. Carsten Grashoff, University of Munster (www.uni-muenster.de/Biologie.IMZ...)
@ 10.00 AM EST, 16:00 CET

Interested in nuclear mechanobiology and attending the ASCBiology/EMBO Cellbio2023 meeting in Boston next week?
Make sure to visit the "Nuclear Mechanobiology" subgroup session on Saturday, Dec. 2, from 1:00 to 3:30pm with an excellent lineup of speakers.
plan.core-apps.com/ascbembo2023...