@lakshyabajaj.bsky.social
Reposted
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
www.biorxiv.org
November 27, 2024 at 1:38 PM
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Paul Lee just gave a brilliant presentation of his thesis work in Junjie Guo’s showing that non-AUG translation of NPR in neurons can be robust owing to cis-signals and can produce a secreted protein isoform in this case, ultimately affecting learning and memory! pubmed.ncbi.nlm.nih.gov/39317199/
Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions - PubMed
While many mRNAs contain more than one translation initiation site (TIS), the functions of most alternative TISs and their corresponding protein isoforms (proteoforms) remain undetermined. Here, we sh...
pubmed.ncbi.nlm.nih.gov
November 12, 2024 at 3:13 PM
Paul Lee just gave a brilliant presentation of his thesis work in Junjie Guo’s showing that non-AUG translation of NPR in neurons can be robust owing to cis-signals and can produce a secreted protein isoform in this case, ultimately affecting learning and memory! pubmed.ncbi.nlm.nih.gov/39317199/
Reposted
Team IDs astrocytes' role in removing toxic brain proteins via autophagy. New approach targets non-neuronal cells, showing promise for memory recovery. Possible dementia treatment? 🧠🔬 #AlzheimersResearch #Neuroscience @KISTKOREA scienceblog.com/548154/new-b...
New brain cell cleaner: astrocytes raise possibility of Alzheimer’s disease treatment
A research team led by Dr. Hoon Ryu from the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh) Brain Disease Research Group, in
scienceblog.com
September 30, 2024 at 1:27 PM
Team IDs astrocytes' role in removing toxic brain proteins via autophagy. New approach targets non-neuronal cells, showing promise for memory recovery. Possible dementia treatment? 🧠🔬 #AlzheimersResearch #Neuroscience @KISTKOREA scienceblog.com/548154/new-b...
Reposted
"While initially the field anticipated that insertions might more commonly “drive” cancers as insertional mutagens, this seems not to be the rule. Interest now is shifting toward understanding the influence of LINE-1 and retrotransposons on cancer biology"
genesdev.cshlp.org/content/37/2...
genesdev.cshlp.org/content/37/2...
LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunitie...
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
January 11, 2024 at 11:40 PM
"While initially the field anticipated that insertions might more commonly “drive” cancers as insertional mutagens, this seems not to be the rule. Interest now is shifting toward understanding the influence of LINE-1 and retrotransposons on cancer biology"
genesdev.cshlp.org/content/37/2...
genesdev.cshlp.org/content/37/2...
Reposted
This is so cool!
Retrotransposons activate during pregnancy to force a swift creation of new RBCs. An example of "junk DNA" being incredibly useful.
And yes, interesting re: cases of #MECFS after pregnancy or recovery after pregnancy. 🧪 www.science.org/doi/10.1126/...
Retrotransposons activate during pregnancy to force a swift creation of new RBCs. An example of "junk DNA" being incredibly useful.
And yes, interesting re: cases of #MECFS after pregnancy or recovery after pregnancy. 🧪 www.science.org/doi/10.1126/...
Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis
Hematopoietic stem cells (HSCs) and erythropoiesis are activated during pregnancy and after bleeding by the derepression of retrotransposons, including endogenous retroviruses and LINE elements. Retro...
www.science.org
October 30, 2024 at 12:53 PM
This is so cool!
Retrotransposons activate during pregnancy to force a swift creation of new RBCs. An example of "junk DNA" being incredibly useful.
And yes, interesting re: cases of #MECFS after pregnancy or recovery after pregnancy. 🧪 www.science.org/doi/10.1126/...
Retrotransposons activate during pregnancy to force a swift creation of new RBCs. An example of "junk DNA" being incredibly useful.
And yes, interesting re: cases of #MECFS after pregnancy or recovery after pregnancy. 🧪 www.science.org/doi/10.1126/...