Karim Labib
@labiblab.bsky.social
We study chromosome replication and genome integrity in Dundee, the city of Discovery in Scotland’s middle-east.
We have postdoctoral positions available, if you might like to join us to study genome integrity in the beautiful east of Scotland. If you're interested, please contact me at kpmlabib@dundee.ac.uk
February 3, 2025 at 1:19 PM
We have postdoctoral positions available, if you might like to join us to study genome integrity in the beautiful east of Scotland. If you're interested, please contact me at kpmlabib@dundee.ac.uk
Complementary work from the Walter & Pellman groups:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TTF2 promotes replisome eviction from stalled forks in mitosis
When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitig...
www.biorxiv.org
February 3, 2025 at 1:05 PM
Complementary work from the Walter & Pellman groups:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Here's out latest manuscript, showing how the replisome is marked for destruction during mitosis, to trigger the processing of sites of incomplete DNA replication.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε
Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of replication forks to facilitate chromosome segregation. The TRAIP ubiquitin ligase i...
www.biorxiv.org
February 3, 2025 at 1:00 PM
Here's out latest manuscript, showing how the replisome is marked for destruction during mitosis, to trigger the processing of sites of incomplete DNA replication.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...