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kuroiikawa.bsky.social
Pathfindingway Kuro
@kuroiikawa.bsky.social
300 followers 340 following 770 posts
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Reposted by Pathfindingway Kuro
internethippo.bsky.social
It's maddening that it's considered smart politics to meekly mumble these idiotic slogans in response to being called Socialist instead of saying "Yeah asshole it's good when people have enough to live on and it's bad when billionaire sociopaths abuse us all"
November 30, 2025 at 4:06 PM
Reposted by Pathfindingway Kuro
sailorrooscout.bsky.social
Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS).

The study has been published in Science Advances. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

🧪🧵⬇️
ABSTRACT Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV. Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose. Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion. These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.
November 28, 2025 at 5:02 PM