Kal Tsanov
LightNews LightNews
ktsanov.bsky.social
Kal Tsanov
@ktsanov.bsky.social
130 followers 120 following 10 posts
Assistant Professor at UChicago
cancer • epi/genetics • metastasis
Posts Replies Media Videos
ktsanov.bsky.social
Many thanks to #AmyGladstein & #DavidFeldser for this great perspective on our recent paper @natcancer.nature.com. As they say in it (and have elegantly shown in their work): "‘Flip the switch’ and let nature show you the way!" 🔦🧬🐭
www.nature.com/articles/s43...
Primary tumor chromatin landscape governs metastatic organotropism - Nature Cancer
Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether sustained inactivation of such genes influences tumor maintenance at these sites...
www.nature.com
October 15, 2025 at 9:32 PM
ktsanov.bsky.social
🚨Location, location, location! Now out @natcancer.nature.com, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation as in pancreatic cancer as a clinically relevant example: nature.com/articles/s43.... (1/4)
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence - Nature Cancer
Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.
nature.com
September 25, 2025 at 4:02 PM