As we reflect on these pioneers, it’s fascinating how their contributions shaped modern medicine and the ethical frameworks we adhere to today in clinical trials.

#ClinicalTrials #MedicalHistory
Figure 1. AI-generated picture from the prompt a researcher in the laboratory.

Hill’s trial introduced robust methodologies we now consider foundational to clinical research: randomization, control groups, and blinding. This marked a significant leap forward in our quest for reliable medical evidence. 📊

Yet, while Lind laid the groundwork it wasn’t until 1948 that we witnessed the first true randomized and double-blinded clinical trial, conducted by Austin Bradford Hill at London Hospital. This landmark study involved 107 patients with tuberculosis and aimed to evaluate the efficacy of streptomycin

Lind’s method was innovative for his time. He selected 12 sailors with scurvy, pairing them up and assigning different treatments. The results?
Those who received the citrus fruits with their vitamin C content showed remarkable improvement.

He set out to find an effective treatment for scurvy, a disease that plagued sailors during long voyages, causing fatigue and devastating symptoms.

It’s not only a first analysis of the clinical pipelines of AI-native Biotech companies but also an early glimpse of the exciting clinical potential of AI-discovered molecules.💥

Source: www.efpia.eu/media/0ipkat...
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W ciągu ostatniej dekady nastąpił globalny ⬆️ BK o 38%, ale w tym samym czasie globalny udział EOG w BK ⬇️ o 50%.
Udział EOG w komercyjnych BK zmniejszył się z 22% w 2013r. do 18% w 2018r. i 12% w 2023r. Autorzy wskazują, że mniej korzystne otoczenie regulacyjne i finansowe to główne przyczyny ⬇️

I would be more than happy to join this group! Can you please add me? 🦋