Kristy Ainslie's Lab
@kristy-ainslie-lab.bsky.social
Researching new vaccines & drug delivery methods to treat infectious & autoimmune diseases & cancer. 🏳️🌈 Ally. Mom 2 boys. She/her/hers. Chem Engineer. Views are my own.
My ERA commons is broken! 😆🫠
November 21, 2025 at 3:09 PM
My ERA commons is broken! 😆🫠
New preprint!
We evaluated 343 analogs of AR-12 (OSU-03012), a compound with host-directed anti-leishmanial activity. w/ RTI & Duke Chem, we identified the lysosome as a new anti-leishmanial target and developed analogs with improved potency and safety.
www.biorxiv.org/content/10.1...
We evaluated 343 analogs of AR-12 (OSU-03012), a compound with host-directed anti-leishmanial activity. w/ RTI & Duke Chem, we identified the lysosome as a new anti-leishmanial target and developed analogs with improved potency and safety.
www.biorxiv.org/content/10.1...
November 5, 2025 at 1:49 PM
New preprint!
We evaluated 343 analogs of AR-12 (OSU-03012), a compound with host-directed anti-leishmanial activity. w/ RTI & Duke Chem, we identified the lysosome as a new anti-leishmanial target and developed analogs with improved potency and safety.
www.biorxiv.org/content/10.1...
We evaluated 343 analogs of AR-12 (OSU-03012), a compound with host-directed anti-leishmanial activity. w/ RTI & Duke Chem, we identified the lysosome as a new anti-leishmanial target and developed analogs with improved potency and safety.
www.biorxiv.org/content/10.1...
While waiting for election results, I asked ChatGPT for the top 50 synthetic polymers used in drug delivery - with discovery years and references.
It got 35% of the years right and only 1 correct reference out of 40!
ainslielab.web.unc.edu/wp-content/u...
It got 35% of the years right and only 1 correct reference out of 40!
ainslielab.web.unc.edu/wp-content/u...
November 5, 2025 at 3:10 AM
While waiting for election results, I asked ChatGPT for the top 50 synthetic polymers used in drug delivery - with discovery years and references.
It got 35% of the years right and only 1 correct reference out of 40!
ainslielab.web.unc.edu/wp-content/u...
It got 35% of the years right and only 1 correct reference out of 40!
ainslielab.web.unc.edu/wp-content/u...
Thrilled to congratulate Elizabeth Gurysh on her first-author paper in Nature Portfolio, showcasing exciting work on immunotherapy-driven clearance of orthotopic glioblastoma.
Open Access: rdcu.be/eIJmv
Open Access: rdcu.be/eIJmv
September 29, 2025 at 6:03 PM
Thrilled to congratulate Elizabeth Gurysh on her first-author paper in Nature Portfolio, showcasing exciting work on immunotherapy-driven clearance of orthotopic glioblastoma.
Open Access: rdcu.be/eIJmv
Open Access: rdcu.be/eIJmv
Group lunch at the newly reopened Med Deli! Great to see it open again and wonderful food as always!
September 15, 2025 at 5:00 PM
Group lunch at the newly reopened Med Deli! Great to see it open again and wonderful food as always!
Congrats High School student Jacob Bachelder on your first author pre-print publication in Chemrxiv! "Six-Array Transepithelial Electrical Resistance Device"
doi.org/10.26434/che...
doi.org/10.26434/che...
September 14, 2025 at 12:26 AM
Congrats High School student Jacob Bachelder on your first author pre-print publication in Chemrxiv! "Six-Array Transepithelial Electrical Resistance Device"
doi.org/10.26434/che...
doi.org/10.26434/che...
Congrats Ryan Woodring on your 1st author pub "Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy"
Open Access: go.unc.edu/AinslieLabTMZ
Open Access: go.unc.edu/AinslieLabTMZ
September 13, 2025 at 3:03 PM
Congrats Ryan Woodring on your 1st author pub "Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy"
Open Access: go.unc.edu/AinslieLabTMZ
Open Access: go.unc.edu/AinslieLabTMZ
Over the years, I’ve baked cupcakes for lab members’ birthdays, colleagues at work, and friends in my neighborhood. Some of the students in the division asked me to collect the recipes, so I’ve put them together in a free PDF download: go.unc.edu/Cakes
Enjoy! 🧁
Enjoy! 🧁
September 5, 2025 at 11:21 PM
Over the years, I’ve baked cupcakes for lab members’ birthdays, colleagues at work, and friends in my neighborhood. Some of the students in the division asked me to collect the recipes, so I’ve put them together in a free PDF download: go.unc.edu/Cakes
Enjoy! 🧁
Enjoy! 🧁
Two memes of the week this week!
August 27, 2025 at 12:14 AM
Two memes of the week this week!
Welcoming the lab back to the 1st week of classes w/ homemade lunch!
Korean beef rice bowl, Roasted veggie over an orzo, garbanzo & feta salad, Southwest chix farro bowl w/ grilled corn, black beans, pico de gallo, roasted onion & peppers, & cauliflower & Cashew barley bowl with baked tofu
Korean beef rice bowl, Roasted veggie over an orzo, garbanzo & feta salad, Southwest chix farro bowl w/ grilled corn, black beans, pico de gallo, roasted onion & peppers, & cauliflower & Cashew barley bowl with baked tofu
August 17, 2025 at 12:50 PM
Welcoming the lab back to the 1st week of classes w/ homemade lunch!
Korean beef rice bowl, Roasted veggie over an orzo, garbanzo & feta salad, Southwest chix farro bowl w/ grilled corn, black beans, pico de gallo, roasted onion & peppers, & cauliflower & Cashew barley bowl with baked tofu
Korean beef rice bowl, Roasted veggie over an orzo, garbanzo & feta salad, Southwest chix farro bowl w/ grilled corn, black beans, pico de gallo, roasted onion & peppers, & cauliflower & Cashew barley bowl with baked tofu
Our lab's meme of the week this week! I'm a sucker for any Schitt's Creek meme.
August 15, 2025 at 12:39 PM
Our lab's meme of the week this week! I'm a sucker for any Schitt's Creek meme.
Some lab birthday treats from this summer. Double decadence brownies, peach upside down cake, lemon cupcakes, and reverse cookies & cream cupcakes.
August 14, 2025 at 12:37 AM
Some lab birthday treats from this summer. Double decadence brownies, peach upside down cake, lemon cupcakes, and reverse cookies & cream cupcakes.
I’m looking forward to presenting at the Controlled Release Society Annual Meeting today during Tech Session VI: Immuno Delivery III!
🗓 Thursday, July 17, 2025
🕟 4:30 PM EDT
📍 Room 119 B
🗓 Thursday, July 17, 2025
🕟 4:30 PM EDT
📍 Room 119 B
July 17, 2025 at 12:41 PM
I’m looking forward to presenting at the Controlled Release Society Annual Meeting today during Tech Session VI: Immuno Delivery III!
🗓 Thursday, July 17, 2025
🕟 4:30 PM EDT
📍 Room 119 B
🗓 Thursday, July 17, 2025
🕟 4:30 PM EDT
📍 Room 119 B
JCR Article double feature alert!
Intranasal influenza vaccine w/ a nanocomplex particulate adjuvant targeting mast cells & TLR9
doi.org/10.1016/j.jc...
Multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates doi.org/10.1016/j.jc...
@dpmp-unc.bsky.social
Intranasal influenza vaccine w/ a nanocomplex particulate adjuvant targeting mast cells & TLR9
doi.org/10.1016/j.jc...
Multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates doi.org/10.1016/j.jc...
@dpmp-unc.bsky.social
July 17, 2025 at 12:40 PM
JCR Article double feature alert!
Intranasal influenza vaccine w/ a nanocomplex particulate adjuvant targeting mast cells & TLR9
doi.org/10.1016/j.jc...
Multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates doi.org/10.1016/j.jc...
@dpmp-unc.bsky.social
Intranasal influenza vaccine w/ a nanocomplex particulate adjuvant targeting mast cells & TLR9
doi.org/10.1016/j.jc...
Multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates doi.org/10.1016/j.jc...
@dpmp-unc.bsky.social
Inspired by CRS meeting - A new Micro/Nanotechnology for Therapeutic, Vaccine, and Imaging Applications timeline!
Original article Stiepel et al.: doi.org/10.1002/btm2...
Link timelines: ainslielab.web.unc.edu/support/
Editable timeline: docs.google.com/presentation...
@dpmp-unc.bsky.social
Original article Stiepel et al.: doi.org/10.1002/btm2...
Link timelines: ainslielab.web.unc.edu/support/
Editable timeline: docs.google.com/presentation...
@dpmp-unc.bsky.social
July 17, 2025 at 12:36 PM
Inspired by CRS meeting - A new Micro/Nanotechnology for Therapeutic, Vaccine, and Imaging Applications timeline!
Original article Stiepel et al.: doi.org/10.1002/btm2...
Link timelines: ainslielab.web.unc.edu/support/
Editable timeline: docs.google.com/presentation...
@dpmp-unc.bsky.social
Original article Stiepel et al.: doi.org/10.1002/btm2...
Link timelines: ainslielab.web.unc.edu/support/
Editable timeline: docs.google.com/presentation...
@dpmp-unc.bsky.social
Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo!
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
July 16, 2025 at 11:59 AM
Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo!
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
I’m looking forward to presenting at the CRS Meeting Thursday during Tech Session VI: Immuno Delivery III!
🗓 Thurs 7/17/25
🕟 4:30 PM
📍 Room 119 B
My talk, “Engineering Tolerance: Acetalated Dextran Microparticles in the Generation of B-regs and T-regs,”
🗓 Thurs 7/17/25
🕟 4:30 PM
📍 Room 119 B
My talk, “Engineering Tolerance: Acetalated Dextran Microparticles in the Generation of B-regs and T-regs,”
July 16, 2025 at 11:55 AM
I’m looking forward to presenting at the CRS Meeting Thursday during Tech Session VI: Immuno Delivery III!
🗓 Thurs 7/17/25
🕟 4:30 PM
📍 Room 119 B
My talk, “Engineering Tolerance: Acetalated Dextran Microparticles in the Generation of B-regs and T-regs,”
🗓 Thurs 7/17/25
🕟 4:30 PM
📍 Room 119 B
My talk, “Engineering Tolerance: Acetalated Dextran Microparticles in the Generation of B-regs and T-regs,”
Great to visit UMich Pharmacy and thanks for the swag!
July 12, 2025 at 9:05 PM
Great to visit UMich Pharmacy and thanks for the swag!
Congrats Nicole Rose on your successful PhD defense!! 🎉🎉
July 7, 2025 at 7:11 PM
Congrats Nicole Rose on your successful PhD defense!! 🎉🎉
Pics from Nicole's graduation party! 🎉🎉
July 2, 2025 at 11:44 AM
Pics from Nicole's graduation party! 🎉🎉
July 1, 2025 at 12:00 PM
A peach upside down cake for my lab tech Allie's birthday! 🍑
July 1, 2025 at 12:11 AM
A peach upside down cake for my lab tech Allie's birthday! 🍑
What's $40k+ a year in unexpected publishing costs in these turbulent times! 😆😭
June 17, 2025 at 6:44 PM
What's $40k+ a year in unexpected publishing costs in these turbulent times! 😆😭
Some reverse cookies and cream cupcakes made with Chocolate Pretzel Oreos for a lab member's bday
June 17, 2025 at 11:15 AM
Some reverse cookies and cream cupcakes made with Chocolate Pretzel Oreos for a lab member's bday
50d free: authors.elsevier.com/a/1lF6fcI2-9...
"Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates"
We show that changing polymer particle degradation rate in a multivalent influenza vaccine can reduce antigen dominance.
"Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates"
We show that changing polymer particle degradation rate in a multivalent influenza vaccine can reduce antigen dominance.
June 10, 2025 at 10:24 PM
50d free: authors.elsevier.com/a/1lF6fcI2-9...
"Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates"
We show that changing polymer particle degradation rate in a multivalent influenza vaccine can reduce antigen dominance.
"Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates"
We show that changing polymer particle degradation rate in a multivalent influenza vaccine can reduce antigen dominance.