Cheng-Yu "Kou" Huang
@koushouu.bsky.social
Quantitative biologist, focus on neuroscience of spatial navigation
Reposted by Cheng-Yu "Kou" Huang
We discovered how an engineered ribosome arrest peptide (eRAP) acts as a built-in “pause button” to precisely control protein synthesis. eRAP merges two natural stalling systems to stop the ribosome at just the right time — shaping how nascent proteins begin to fold.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Validate User
academic.oup.com
October 15, 2025 at 2:28 AM
We discovered how an engineered ribosome arrest peptide (eRAP) acts as a built-in “pause button” to precisely control protein synthesis. eRAP merges two natural stalling systems to stop the ribosome at just the right time — shaping how nascent proteins begin to fold.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Cheng-Yu "Kou" Huang
Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
Nature Communications - K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin...
rdcu.be
October 15, 2025 at 10:16 AM
Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM
Reposted by Cheng-Yu "Kou" Huang
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Learning produces an orthogonalized state machine in the hippocampus
YouTube video by Weinan Sun
www.youtube.com
February 12, 2025 at 7:36 PM
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Reposted by Cheng-Yu "Kou" Huang
Good papers lead to more questions than they answer. That's because (as Blaise Pascal wrote) knowledge is like a sphere: the larger it gets the larger also its surface, which is its interface with the unknown.
January 2, 2025 at 11:23 PM
Good papers lead to more questions than they answer. That's because (as Blaise Pascal wrote) knowledge is like a sphere: the larger it gets the larger also its surface, which is its interface with the unknown.