Hans Oh
@kmshoh.bsky.social
MD/PhD @UPenn | Medicinal Chemistry @SGC-UNC
Excited to present our lab's work on identifying new nsP2 helicase inhibitors with antiviral activity against chikunguya (pubs.acs.org/doi/10.1021/...)
Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity
Alphaviruses are mosquito-borne RNA viruses that pose a significant public health threat, with no FDA-approved antiviral therapeutics available. The nonstructural protein 2 helicase (nsP2hel) is an en...
pubs.acs.org
July 19, 2025 at 7:56 PM
Excited to present our lab's work on identifying new nsP2 helicase inhibitors with antiviral activity against chikunguya (pubs.acs.org/doi/10.1021/...)
Check out our new pre-print on the discovery of nsP2 helicase inhibitors! #chembio #medchem www.biorxiv.org/content/10.1...
Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity
Alphaviruses are mosquito-borne RNA viruses that pose a significant public health threat, with no FDA-approved antiviral therapeutics available. The non-structural protein 2 helicase (nsP2hel) is an e...
www.biorxiv.org
March 10, 2025 at 9:19 PM
Check out our new pre-print on the discovery of nsP2 helicase inhibitors! #chembio #medchem www.biorxiv.org/content/10.1...
Happy to see our story on brachyury published in Nature Communications! We use crystallographic fragment screening to identity multiple fragment hits for potential inhibitor and degrader development. doi.org/10.1038/s414...
Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy - Nature Communications
This study describes structures of the transcription factor brachyury revealing the mechanism of DNA recognition. They identify fragments using X-ray fragment screening and optimize these into potent ...
doi.org
February 15, 2025 at 10:35 PM
Happy to see our story on brachyury published in Nature Communications! We use crystallographic fragment screening to identity multiple fragment hits for potential inhibitor and degrader development. doi.org/10.1038/s414...