Kelly Magliocca DDS, MPH
@kmagliocca.bsky.social
Oral, Head and Neck Pathology I Service Director H&N Pathology I Professor @emorypathology.bsky.social
Frozen-section-Friday:
Adult with 2 cm parotid mass sent for intraoperative consultation
📸: solitary, largely circumscribed, cut surface w internal heterogeneity
📸: touch prep - monotonous cells (myoeps) w/i basophilic matrix
📸: low mag nodule contour at frozen section
…next
#PathSky #ENTsky
Adult with 2 cm parotid mass sent for intraoperative consultation
📸: solitary, largely circumscribed, cut surface w internal heterogeneity
📸: touch prep - monotonous cells (myoeps) w/i basophilic matrix
📸: low mag nodule contour at frozen section
…next
#PathSky #ENTsky
November 21, 2025 at 3:40 PM
Partial auriculectomy for basal cell carcinoma (not shown) in pt with known history of Darier disease
📸 macro: portion of helix, formalin-fixed with multiple punctate lesions (arrow) and small plaques
📸 macro, cut-surface: firm, rust/white colored plaques confined to epidermis
#dermpath #Pathsky
📸 macro: portion of helix, formalin-fixed with multiple punctate lesions (arrow) and small plaques
📸 macro, cut-surface: firm, rust/white colored plaques confined to epidermis
#dermpath #Pathsky
November 9, 2025 at 2:56 PM
Reposted by Kelly Magliocca DDS, MPH
Parasagittal section through total laryngectomy specimen resected for advanced stage squamous cell carcinoma. Curious finding in the blue box
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
July 26, 2025 at 4:18 PM
Parasagittal section through total laryngectomy specimen resected for advanced stage squamous cell carcinoma. Curious finding in the blue box
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
Reposted by Kelly Magliocca DDS, MPH
These tyrosine-like crystalloids seem to localize most frequently to the true cord, particularly near the macula flava
PMID: 39177813
PMID: 39177813
July 26, 2025 at 4:21 PM
These tyrosine-like crystalloids seem to localize most frequently to the true cord, particularly near the macula flava
PMID: 39177813
PMID: 39177813
Biopsy of anterior true vocal cord, sent for intraop consult. Pt with history of glottic squamous cell ca, s/p radiation therapy. Biopsy neg for scca. However…
📸 tyrosine-like crystalloids w/i anterior macula flava (is chondroid here)
📸 TLCs not commonly seen at frozens
PMID: 39177813
#Pathsky
📸 tyrosine-like crystalloids w/i anterior macula flava (is chondroid here)
📸 TLCs not commonly seen at frozens
PMID: 39177813
#Pathsky
November 6, 2025 at 6:20 PM
Biopsy of anterior true vocal cord, sent for intraop consult. Pt with history of glottic squamous cell ca, s/p radiation therapy. Biopsy neg for scca. However…
📸 tyrosine-like crystalloids w/i anterior macula flava (is chondroid here)
📸 TLCs not commonly seen at frozens
PMID: 39177813
#Pathsky
📸 tyrosine-like crystalloids w/i anterior macula flava (is chondroid here)
📸 TLCs not commonly seen at frozens
PMID: 39177813
#Pathsky
Adult male; White corrugated plaque on lateral oral tongue
Dx: oral hairy leukoplakia
Low: epithelial hyperplasia, shaggy corrugated parakeratotic surface, often pallor in spinous layer
High: perinuclear clearing, nuclear beading
EBV ISH (red): nuclear signal in affected cells
#PathSky
Dx: oral hairy leukoplakia
Low: epithelial hyperplasia, shaggy corrugated parakeratotic surface, often pallor in spinous layer
High: perinuclear clearing, nuclear beading
EBV ISH (red): nuclear signal in affected cells
#PathSky
November 3, 2025 at 6:40 PM
Adult male; White corrugated plaque on lateral oral tongue
Dx: oral hairy leukoplakia
Low: epithelial hyperplasia, shaggy corrugated parakeratotic surface, often pallor in spinous layer
High: perinuclear clearing, nuclear beading
EBV ISH (red): nuclear signal in affected cells
#PathSky
Dx: oral hairy leukoplakia
Low: epithelial hyperplasia, shaggy corrugated parakeratotic surface, often pallor in spinous layer
High: perinuclear clearing, nuclear beading
EBV ISH (red): nuclear signal in affected cells
#PathSky
Solitary, exophytic nodule at posterior dorsal tongue.
Dx: lingual osseous choristoma
📸: oral mucosa with central focus of dense lamellar bone
📸: relation of bone to overlying oral squamous epithelium
📸: lamellar bone (slightly over-decal’d) with evidence of remodeling
#PathSky #ENTsky
Dx: lingual osseous choristoma
📸: oral mucosa with central focus of dense lamellar bone
📸: relation of bone to overlying oral squamous epithelium
📸: lamellar bone (slightly over-decal’d) with evidence of remodeling
#PathSky #ENTsky
October 27, 2025 at 9:46 PM
Mid-30’s FM w/progressive conductive hearing loss. Clin dx: otosclerosis
Intraop: stapes fixed, remainder of ossicular chain mobile.
📸: stapes with remodeling, transected above footplate
📸: evolving pseudocyst w/i the articular surface (reactive)
#PathSky #ENTpath #PathTwitter #EmoryPathology
Intraop: stapes fixed, remainder of ossicular chain mobile.
📸: stapes with remodeling, transected above footplate
📸: evolving pseudocyst w/i the articular surface (reactive)
#PathSky #ENTpath #PathTwitter #EmoryPathology
October 27, 2025 at 3:37 PM
Mid-30’s FM w/progressive conductive hearing loss. Clin dx: otosclerosis
Intraop: stapes fixed, remainder of ossicular chain mobile.
📸: stapes with remodeling, transected above footplate
📸: evolving pseudocyst w/i the articular surface (reactive)
#PathSky #ENTpath #PathTwitter #EmoryPathology
Intraop: stapes fixed, remainder of ossicular chain mobile.
📸: stapes with remodeling, transected above footplate
📸: evolving pseudocyst w/i the articular surface (reactive)
#PathSky #ENTpath #PathTwitter #EmoryPathology
📸Transverse section through the cricoarytenoid joint (CAJ) of the larynx, a true synovial joint. Arrows delineate joint space
📸 Same, just higher mag
📸 Generally surfaced by fibrocartilage (but may be mixed). Synovium present
📸 Synovial lining
#PathSky #ENTPath #PathTwitter
#EmoryPathology
📸 Same, just higher mag
📸 Generally surfaced by fibrocartilage (but may be mixed). Synovium present
📸 Synovial lining
#PathSky #ENTPath #PathTwitter
#EmoryPathology
October 20, 2025 at 10:02 PM
📸Transverse section through the cricoarytenoid joint (CAJ) of the larynx, a true synovial joint. Arrows delineate joint space
📸 Same, just higher mag
📸 Generally surfaced by fibrocartilage (but may be mixed). Synovium present
📸 Synovial lining
#PathSky #ENTPath #PathTwitter
#EmoryPathology
📸 Same, just higher mag
📸 Generally surfaced by fibrocartilage (but may be mixed). Synovium present
📸 Synovial lining
#PathSky #ENTPath #PathTwitter
#EmoryPathology
Squamous cell carcinoma of the edentulous alveolar ridge and palate. Cut surface (ms=maxillary sinus; nc=nasal cavity); corresponding low mag image; endophytic (arrow) with cystic cuniculatum-like growth; additional cystic change in scca.
#PathSky #ENTPath #HeadNeckPath #OralPath #PathTwitter
#PathSky #ENTPath #HeadNeckPath #OralPath #PathTwitter
October 13, 2025 at 4:21 PM
Squamous cell carcinoma of the edentulous alveolar ridge and palate. Cut surface (ms=maxillary sinus; nc=nasal cavity); corresponding low mag image; endophytic (arrow) with cystic cuniculatum-like growth; additional cystic change in scca.
#PathSky #ENTPath #HeadNeckPath #OralPath #PathTwitter
#PathSky #ENTPath #HeadNeckPath #OralPath #PathTwitter
Nasopharyngeal mass, adult male.
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
August 19, 2025 at 10:04 PM
Nasopharyngeal mass, adult male.
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
Expansile sinonasal mass, adult FM:
Dx: Epithelial-myoepithelial carcinoma. Biphasic salivary gland carcinoma composed of tightly coupled eosinophilic ductal cells and abluminal myoepithelial cells. Diffuse RAS Q61R IHC expression supportive while working thru the ddx.
PMID: 33481388
#PathSky
Dx: Epithelial-myoepithelial carcinoma. Biphasic salivary gland carcinoma composed of tightly coupled eosinophilic ductal cells and abluminal myoepithelial cells. Diffuse RAS Q61R IHC expression supportive while working thru the ddx.
PMID: 33481388
#PathSky
August 15, 2025 at 1:49 PM
Expansile sinonasal mass, adult FM:
Dx: Epithelial-myoepithelial carcinoma. Biphasic salivary gland carcinoma composed of tightly coupled eosinophilic ductal cells and abluminal myoepithelial cells. Diffuse RAS Q61R IHC expression supportive while working thru the ddx.
PMID: 33481388
#PathSky
Dx: Epithelial-myoepithelial carcinoma. Biphasic salivary gland carcinoma composed of tightly coupled eosinophilic ductal cells and abluminal myoepithelial cells. Diffuse RAS Q61R IHC expression supportive while working thru the ddx.
PMID: 33481388
#PathSky
Adult FM with temporomandibular osteoarthritis
Dx: Subchondral cyst (SC)
SC identified on sagittal CT & subsequently on microscopic examination. 📸➡️ TMJ SC is spherical subchondral lesion w/myxoid change surrounded by reactive bone. Articular cartilage with degenerative changes.
#PathSky #RadSky
Dx: Subchondral cyst (SC)
SC identified on sagittal CT & subsequently on microscopic examination. 📸➡️ TMJ SC is spherical subchondral lesion w/myxoid change surrounded by reactive bone. Articular cartilage with degenerative changes.
#PathSky #RadSky
August 13, 2025 at 2:06 PM
DICER1-associated atrophic changes in this min. invasive FTC. Rim of pale, flattened tumor cells adjacent to non-affected tumor. Circumferential, no cellular debris, apoptotics or inflammation; argues against necrosis.
🙌 🙏 to author KV in PMID:38637342 for teaching me!
#PathSky #Thyroid #Endosky
🙌 🙏 to author KV in PMID:38637342 for teaching me!
#PathSky #Thyroid #Endosky
August 11, 2025 at 2:03 PM
Lytic lesion of mandible, prior extraction site; years ago.
Myospherulosis represents altered RBCs in cyst-like spaces, surrounded by fibrosis. At high magnification, note the pigmented spherical bodies (‘bag of marbles’). Potentially a fungal mimic ➡️ PAS/GMS neg.
#PathSky #OralPath #PathTwitter
Myospherulosis represents altered RBCs in cyst-like spaces, surrounded by fibrosis. At high magnification, note the pigmented spherical bodies (‘bag of marbles’). Potentially a fungal mimic ➡️ PAS/GMS neg.
#PathSky #OralPath #PathTwitter
August 9, 2025 at 9:37 PM
Lytic lesion of mandible, prior extraction site; years ago.
Myospherulosis represents altered RBCs in cyst-like spaces, surrounded by fibrosis. At high magnification, note the pigmented spherical bodies (‘bag of marbles’). Potentially a fungal mimic ➡️ PAS/GMS neg.
#PathSky #OralPath #PathTwitter
Myospherulosis represents altered RBCs in cyst-like spaces, surrounded by fibrosis. At high magnification, note the pigmented spherical bodies (‘bag of marbles’). Potentially a fungal mimic ➡️ PAS/GMS neg.
#PathSky #OralPath #PathTwitter
Submandibular sialolith is a gross-only specimen for us. However…the interesting surface texture piqued my interest. Intact appearance, sectioned, faxitron (in our lab) and low mag histology with arrows highlighting the textured region.
#PathSky #RadSky #OralPath #ENTPath #HeadNeckPath
#PathSky #RadSky #OralPath #ENTPath #HeadNeckPath
August 8, 2025 at 1:57 PM
Submandibular sialolith is a gross-only specimen for us. However…the interesting surface texture piqued my interest. Intact appearance, sectioned, faxitron (in our lab) and low mag histology with arrows highlighting the textured region.
#PathSky #RadSky #OralPath #ENTPath #HeadNeckPath
#PathSky #RadSky #OralPath #ENTPath #HeadNeckPath
At high magnification, subgemmal neurogenous plaque (normal regional microanatomy) may overlap with neurofibroma: spindle cells, buckled nuclei, collagenous stroma. Key clue: localization near taste buds (s100+/keratin+) in the overlying epithelium.
August 7, 2025 at 8:54 PM
At high magnification, subgemmal neurogenous plaque (normal regional microanatomy) may overlap with neurofibroma: spindle cells, buckled nuclei, collagenous stroma. Key clue: localization near taste buds (s100+/keratin+) in the overlying epithelium.
Sinonasal mass, adult. DEK::AFF2 sinonasal carcinoma, FISH+. We do not have this testing in-house, we used a reference lab in the US for this case. (Attached ancillary testing results were non-specific)
Other sites:
Middle ear/temporal bone: PMID: 32366754
Larynx PMID: 40299135
Lung PMID: 35773081
Other sites:
Middle ear/temporal bone: PMID: 32366754
Larynx PMID: 40299135
Lung PMID: 35773081
August 6, 2025 at 3:06 PM
Sinonasal mass, adult. DEK::AFF2 sinonasal carcinoma, FISH+. We do not have this testing in-house, we used a reference lab in the US for this case. (Attached ancillary testing results were non-specific)
Other sites:
Middle ear/temporal bone: PMID: 32366754
Larynx PMID: 40299135
Lung PMID: 35773081
Other sites:
Middle ear/temporal bone: PMID: 32366754
Larynx PMID: 40299135
Lung PMID: 35773081
Tracheal adenoid cystic carcinoma. At high magnification (next 2 pics), areas of ‘signet-ring like’ or vacuolated, clear cell change is noted in ducts. Unknown clinical significance but when present in small biopsy material, may lead to diagnostic uncertainty.
PMID: 23379326
PMID: 39235305 (fig 3)
PMID: 23379326
PMID: 39235305 (fig 3)
August 4, 2025 at 12:59 PM
Tracheal adenoid cystic carcinoma. At high magnification (next 2 pics), areas of ‘signet-ring like’ or vacuolated, clear cell change is noted in ducts. Unknown clinical significance but when present in small biopsy material, may lead to diagnostic uncertainty.
PMID: 23379326
PMID: 39235305 (fig 3)
PMID: 23379326
PMID: 39235305 (fig 3)
Idiopathic gingival papillokeratosis with crypt formation.
Uncommon. Generally located along anterior maxillary gingiva in young people. Asymptomatic plaque(s), usually bilateral and white in color. No known risk of transformation.
PMID: 28089460
#PathSky #OralPath #ENTPath #EmoryPathology
Uncommon. Generally located along anterior maxillary gingiva in young people. Asymptomatic plaque(s), usually bilateral and white in color. No known risk of transformation.
PMID: 28089460
#PathSky #OralPath #ENTPath #EmoryPathology
July 29, 2025 at 3:06 PM
Idiopathic gingival papillokeratosis with crypt formation.
Uncommon. Generally located along anterior maxillary gingiva in young people. Asymptomatic plaque(s), usually bilateral and white in color. No known risk of transformation.
PMID: 28089460
#PathSky #OralPath #ENTPath #EmoryPathology
Uncommon. Generally located along anterior maxillary gingiva in young people. Asymptomatic plaque(s), usually bilateral and white in color. No known risk of transformation.
PMID: 28089460
#PathSky #OralPath #ENTPath #EmoryPathology
Parasagittal section through total laryngectomy specimen resected for advanced stage squamous cell carcinoma. Curious finding in the blue box
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
July 26, 2025 at 4:18 PM
Parasagittal section through total laryngectomy specimen resected for advanced stage squamous cell carcinoma. Curious finding in the blue box
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
#PathSky #Pathology #ENTPath #HeadNeckPath #EmoryPathology
Endolymphatic sac tumor
July 21, 2025 at 9:05 PM
Endolymphatic sac tumor
