Kesha Josts
@kjosts.bsky.social
NUAcT Fellow and Royal Society URF, Newcastle University
Interested in iron uptake pathways and membrane protein biochemistry/biophysics
Interested in iron uptake pathways and membrane protein biochemistry/biophysics
Reposted by Kesha Josts
Lots of exciting developments to understand the structure of membrane protein in its native environment
Keynote lecture from @stemuench.bsky.social giving us a historical perspective of EM and the exciting challenges left to explore
November 5, 2025 at 11:05 AM
Lots of exciting developments to understand the structure of membrane protein in its native environment
Reposted by Kesha Josts
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
November 2, 2025 at 8:22 PM
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
Reposted by Kesha Josts
Want to find ways to combat TB? Check out this PhD position 👇
November 2, 2025 at 8:44 PM
Want to find ways to combat TB? Check out this PhD position 👇
Reposted by Kesha Josts
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology
Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.
doi.org
October 2, 2025 at 6:20 AM
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
Reposted by Kesha Josts
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 9:29 AM
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
Reposted by Kesha Josts
Fantastic team effort. Project led by PDRA Curtis Cottam, with support from recently recruited PDRA Kieran Bowran and collaborators @kjosts.bsky.social and @rhystwhite.bsky.social . Many thanks to the MRC @ukri.org, @acmedsci.bsky.social and @royalsociety.org for funding our research.
July 30, 2025 at 1:14 PM
Fantastic team effort. Project led by PDRA Curtis Cottam, with support from recently recruited PDRA Kieran Bowran and collaborators @kjosts.bsky.social and @rhystwhite.bsky.social . Many thanks to the MRC @ukri.org, @acmedsci.bsky.social and @royalsociety.org for funding our research.
Reposted by Kesha Josts
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
April 9, 2025 at 5:19 PM
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Reposted by Kesha Josts
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
jobs.ncl.ac.uk
April 9, 2025 at 12:29 PM
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Reposted by Kesha Josts
New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM
February 3, 2025 at 8:52 AM
New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM
Reposted by Kesha Josts
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com
PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com
www.findaphd.com
January 6, 2025 at 9:14 PM
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239