Kitty Murphy
@kittybmurphy.bsky.social
Postdoc at Globe Institute, University of Copenhagen 🇩🇰 she/her
Interested in the phenotypic effects of archaic DNA present in modern human genomes 🧬
Interested in the phenotypic effects of archaic DNA present in modern human genomes 🧬
September 23, 2025 at 6:41 PM
Super excited to see them at Glastonbury this year! 🎪
June 5, 2025 at 9:17 AM
Super excited to see them at Glastonbury this year! 🎪
This was a true team effort, and huge thanks go to everyone involved: @sj-marzi.bsky.social, Di Hu, @bartdestrooper.bsky.social, @mancusorenzo.bsky.social, Leen Wolfs, @susanrohde.bsky.social, Gonzalo Leguía Fauró, and Ivana Geric ✨
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May 28, 2025 at 8:56 PM
This was a true team effort, and huge thanks go to everyone involved: @sj-marzi.bsky.social, Di Hu, @bartdestrooper.bsky.social, @mancusorenzo.bsky.social, Leen Wolfs, @susanrohde.bsky.social, Gonzalo Leguía Fauró, and Ivana Geric ✨
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Lastly, we were excited to find that regions with increased chromatin accessibility in APOE2 microglia were enriched for vitamin D receptor binding, suggesting vitamin D signalling as a potential protective mechanism and therapeutic avenue.
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May 28, 2025 at 8:56 PM
Lastly, we were excited to find that regions with increased chromatin accessibility in APOE2 microglia were enriched for vitamin D receptor binding, suggesting vitamin D signalling as a potential protective mechanism and therapeutic avenue.
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Comparison with independent studies showed that APOE2 microglia were enriched for plaque-phagocytosing genes, prompting us to test their phagocytic activity. Using E. coli and myelin, we found that they were indeed more phagocytic than APOE4 microglia.
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May 28, 2025 at 8:56 PM
Comparison with independent studies showed that APOE2 microglia were enriched for plaque-phagocytosing genes, prompting us to test their phagocytic activity. Using E. coli and myelin, we found that they were indeed more phagocytic than APOE4 microglia.
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Genes downregulated in APOE4-expressing microglia were enriched in putatively protective microglial states, suggesting a failure to transition into these states.
Additionally, cytokine expression was elevated, consistent with previous findings in mouse microglia expressing APOE4.
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Additionally, cytokine expression was elevated, consistent with previous findings in mouse microglia expressing APOE4.
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May 28, 2025 at 8:56 PM
Genes downregulated in APOE4-expressing microglia were enriched in putatively protective microglial states, suggesting a failure to transition into these states.
Additionally, cytokine expression was elevated, consistent with previous findings in mouse microglia expressing APOE4.
4/n
Additionally, cytokine expression was elevated, consistent with previous findings in mouse microglia expressing APOE4.
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We observed consistent differences in gene expression and chromatin accessibility. For example, the cellular migration-related gene CHCHD2 showed higher expression and increased chromatin accessibility near its transcription start site in APOE2 microglia.
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May 28, 2025 at 8:56 PM
We observed consistent differences in gene expression and chromatin accessibility. For example, the cellular migration-related gene CHCHD2 showed higher expression and increased chromatin accessibility near its transcription start site in APOE2 microglia.
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As anticipated, the most pronounced differences were observed between APOE4 (risk-increasing in some populations) and APOE2 (protective).
Expression changes were partly driven by loss of function, but only genes downregulated in APOE4 and KO microglia were enriched for AD risk variants.
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Expression changes were partly driven by loss of function, but only genes downregulated in APOE4 and KO microglia were enriched for AD risk variants.
2/n
May 28, 2025 at 8:56 PM
As anticipated, the most pronounced differences were observed between APOE4 (risk-increasing in some populations) and APOE2 (protective).
Expression changes were partly driven by loss of function, but only genes downregulated in APOE4 and KO microglia were enriched for AD risk variants.
2/n
Expression changes were partly driven by loss of function, but only genes downregulated in APOE4 and KO microglia were enriched for AD risk variants.
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What a line-up! Just in time for international women’s day 💫 congrats!
March 7, 2025 at 5:49 PM
What a line-up! Just in time for international women’s day 💫 congrats!