Kiessling Lab
@kiesslinglab.bsky.social
All things sugars. #glycotime
Run by SYL/JWA
Run by SYL/JWA
Reposted by Kiessling Lab
First post here! To inaugurate this account, I'd like to share my recent work, now published in JACS.
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling
The mycobacterial cell envelope plays both infectious and protective roles. Understanding its structure is crucial for unlocking the molecular basis underlying these functions. Studying glycans, the p...
pubs.acs.org
March 27, 2025 at 6:16 PM
First post here! To inaugurate this account, I'd like to share my recent work, now published in JACS.
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
More things to celebrate from Dec. - papers!
1) Alli's work examining CH-pi interactions computationally is now published in Chem Sci!
pubs.rsc.org/en/content/a...
2) Recent alumni, Deepsing and Deena, published their work on how heparan sulfate influences hPSC fate!
www.cell.com/stem-cell-re...
1) Alli's work examining CH-pi interactions computationally is now published in Chem Sci!
pubs.rsc.org/en/content/a...
2) Recent alumni, Deepsing and Deena, published their work on how heparan sulfate influences hPSC fate!
www.cell.com/stem-cell-re...
Heparan sulfate regulates the fate decisions of human pluripotent stem cells
Kiessling and colleagues developed EXT1−/− hPSCs to investigate the roles of HS polysaccharide in self-renewal and differentiation of hPSCs. The study revealed that HS is essential for early cell fate decisions of hPSCs toward mesoderm and endoderm lineages. HS deficiency allows for early ectoderm differentiation but impairs neuronal maturation.
www.cell.com
January 10, 2025 at 9:12 PM
More things to celebrate from Dec. - papers!
1) Alli's work examining CH-pi interactions computationally is now published in Chem Sci!
pubs.rsc.org/en/content/a...
2) Recent alumni, Deepsing and Deena, published their work on how heparan sulfate influences hPSC fate!
www.cell.com/stem-cell-re...
1) Alli's work examining CH-pi interactions computationally is now published in Chem Sci!
pubs.rsc.org/en/content/a...
2) Recent alumni, Deepsing and Deena, published their work on how heparan sulfate influences hPSC fate!
www.cell.com/stem-cell-re...
December had many celebrations -- including those of our newly minted Ph.D.'s: Alan, Melanie, and Stephanie (@ssmelyansky.bsky.social)! Each of them are fantastic scientists & peer mentors that will excel in their next steps. Join us in congratulating them on completion of their doctoral theses! 🙌🎊
January 9, 2025 at 8:18 PM
December had many celebrations -- including those of our newly minted Ph.D.'s: Alan, Melanie, and Stephanie (@ssmelyansky.bsky.social)! Each of them are fantastic scientists & peer mentors that will excel in their next steps. Join us in congratulating them on completion of their doctoral theses! 🙌🎊
Congrats to our recent Ph.D., Valerie, on this cool review article! Check it out!
Valerie Lensch of @kiesslinglab.bsky.social and the Johnson group reviewed different glycan-based strategies for eliciting an immune response: academic.oup.com/glycob/artic... #glycotime
Glycoconjugate vaccines: platforms and adjuvants for directed immunity
Abstract. Central to immune recognition is the glycocalyx, a glycan-rich coat on all cells that plays a crucial role in interactions that enable pathogen d
academic.oup.com
January 8, 2025 at 4:25 PM
Congrats to our recent Ph.D., Valerie, on this cool review article! Check it out!
Gerard is a trailblazer, inside and outside of the lab! We are fortunate to be his labmates 🧪
“Attending SPISE completely changed my trajectory,” says Gerard Porter of the @kiesslinglab.bsky.social, who credits the five-week program offered by the Caribbean Science Foundation with increasing his self-confidence, reasoning skills, and love of science.
chemistry.mit.edu/chemistry-ne...
chemistry.mit.edu/chemistry-ne...
January 8, 2025 at 4:23 PM
Gerard is a trailblazer, inside and outside of the lab! We are fortunate to be his labmates 🧪
Reposted by Kiessling Lab
Really enjoyed the opportunity to have the @kiesslinglab.bsky.social collaborate with the Imperiali Group on exploring human lectin interactions with glycans. #glycotime Some initial findings are here: www.biorxiv.org/content/10.1...
Glycan analysis probes inspired by human lectins for investigating host-microbe crosstalk
Human lectins are critical carbohydrate-binding proteins that recognize diverse glycoconjugates from microorganisms and can play a key role in host-microbe interactions. Despite their importance in im...
www.biorxiv.org
December 26, 2024 at 9:38 PM
Really enjoyed the opportunity to have the @kiesslinglab.bsky.social collaborate with the Imperiali Group on exploring human lectin interactions with glycans. #glycotime Some initial findings are here: www.biorxiv.org/content/10.1...
We are excited to announce our migration to Bluesky!! 🦋
November 15, 2024 at 4:00 PM
We are excited to announce our migration to Bluesky!! 🦋