Tom Forbes
kidneytom.bsky.social
Tom Forbes
@kidneytom.bsky.social
Some sunset zen from my ride home yesterday. @cityofmelbourne.bsky.social #bike
March 20, 2025 at 8:38 PM
On behalf of the ANZ NKC Chapter, thank you thank you thank you #PSANZ2025 🙏🙏🙏. Huge attendance and great discussion at our symposium today!!! We were just blown away by the enthusiasm and engagement from you all to improve our care and research into neonatal kidney disease.
March 19, 2025 at 6:45 AM
Acute kidney injury is common in NICU admitted infants, and associated with mortality and increased length of stay. AWAKEN is the study that “woke up” the field to this problem, thanks to the Neonatal Kidney Collaborative. #PSANZ2025
March 19, 2025 at 1:49 AM
Very grateful for the opportunity to present our local data-led audit of #AKI at #PSANZ2025. Work made possible by the coding expertise and supervision of Emily See and the amazing resource that is the Centre for Health Analytics at the Melbourne Children’s Campus.
March 18, 2025 at 3:31 AM
Registry information: #IPNA2025
February 22, 2025 at 10:10 AM
Nice summary slide. #IPNA2025
February 22, 2025 at 9:49 AM
CYP34A1 and -A3
Heterozygous or homozygous.
Hypophosphataemia (may be insidious leads to increase in calcitriol levels, leading to hypercalcaemia, hypercalciuria to stones and neohrocalcinosis.
February 22, 2025 at 9:47 AM
Emerging stone forming monogenic kidney diseases with David Sas from Mayo Clinic. #IPNA2025
February 22, 2025 at 9:35 AM
Histology: whilst class of SLE is important, a move to consider activity and chronicity indices as well as remembering that as a rare and very complex disease, cookie cutter classification and treatment is ill advised. #IPNA2025
February 20, 2025 at 10:45 AM
Key message: clinical features don’t accurately reflect renal histology. Low threshold for biopsy. #IPNA2025
February 20, 2025 at 10:42 AM
Complex aetiology including susceptibility risk factors (genetic) and environmental triggers. #IPNA2025
February 20, 2025 at 10:37 AM
ANA 97%, dsDNA 93% and C3/C4 in 78%.
No test is perfect, ‘atypical’ disease is common.
Rheumatology involvement is important.
#IPNA2025
February 20, 2025 at 10:35 AM
Great talk!!
February 20, 2025 at 10:30 AM
Avacopan looking promising in adult studies. Matko discusses that this may improve steroid burden and lead to better outcomes. More studies needed. #IPNA2025
February 20, 2025 at 10:25 AM
Maintenance treatment with rituximab is becoming preferred maintenance therapy over oral antiproliferatives. #IPNA2025
February 20, 2025 at 10:23 AM
Matko Marlais presenting on RPGN in paediatrics in the glomerular disease update. #IPNA2025
February 20, 2025 at 10:17 AM
Immunomonitoring of PLA2R Ab + pts can assist in anticipating clinical relapse and guide therapy. KDIGO guidelines cover decision making here. Studies suggest monitored patients maintain remission better than non-monitored. #IPNA2025
February 20, 2025 at 10:12 AM
STARMEN trial PNL and CYP to TAC and RTX. The former seemed more effective treatment but high steroid load.
February 20, 2025 at 10:07 AM
MENTOR showed us that CNI are good for inducing remission but ritux provides longer periods of remission. #IPNA2025
February 20, 2025 at 10:05 AM
Awesome figure from the Ronco Ped Neph review! The older you are, more likely to be PLA2R+, younger more likely to be SEM3B. Don’t forget rare vertical Ab transmission and BSA cases. #IPNA2025
February 20, 2025 at 10:00 AM
The procession of MN antigens beyond PLA2R.
February 20, 2025 at 9:58 AM
PLA2R: if serum negative can still find in biopsy (serum usually becomes positive later.
PLA2R Ab titre a/w severity. Can use as a treatment binaries, often delayed. Ab reappearance precedes relapse. #IPNA2025
February 20, 2025 at 9:57 AM
Moon Saleem discusses genetic drivers of steroid sensitive nephrotic syndrome, and steroid resistant NS, the latter having some risk alleles that may predict for FSGS in the absence of a monogenic cause. #IPNA2025
February 19, 2025 at 10:54 AM
Current treatment guidelines for RAS inhibition is to start for XLAS and ARAS males at the time of diagnosis. This is a point of difference to other glomerular diseases where we start with onset of proteinuria. #IPNA2025
February 19, 2025 at 10:12 AM
Michelle Rheault presents the Update in Genetic Diseases #IPNA2025 on treatment developments in Alport Syndrome.
First message, Alport Syndrome variants (particularly dominant AS) are more common than previously thought.
@rheaultm.bsky.social
February 19, 2025 at 10:01 AM