Lots more feedback welcome and encouraged in our new manuscripts which we hope to have available on Biorxiv and beyond to all of you, as soon as possible 😊

Then a presentation at the Molecular and cellular biology away day, where we could chat and interact with our peers 😊 A great day!!

Next a presentation at our Institute's annual conference, presenting work from our wonderful lab members Susana and Noa who are on maternity leave and back treating patients in the Marsden, respectively ❤️❤️

First a return to my homeland to reconnect with the many chromatin experts there, as part of the annual Irish Chromatin Consortium 🇮🇪

🤩🤩🤩

Merci David!

PBRM1 null cells have increased whole arm exchanges and DNA recombination at centromeric DNA 🧬 This ultimately leads to a sensitivity of PBRM1 null cells to mitotic perturbation, representing a potential therapeutic sensitivity in PBRM1 mutant cancers 💊

Thanks to lots of proteomics profiling from Theo & the Choudhary lab, we found that PBRM1 loss leads to loss of centromeric protein abundance. PBRM1 null cells also exhibit an altered centromere structure and mislocalisation of pericentromeric heterochromatic marks such as H3K9me3 🔬